/*
 * mutation-combination-detail.css — vista de detalle de una combinación de mutaciones
 *
 * Variables :root con nombres legacy (teal/violet/pink) preservados pero con
 * valores recoloreados a paleta home azul/cyan. Mantienen retrocompatibilidad
 * con cualquier código legacy mientras la apariencia sigue la convención del
 * proyecto.
 *
 * Paleta home azul + cyan + semánticos:
 *   --teal      → azul home oscuro  (#0056a3)
 *   --violet    → azul home medio   (#2563eb)
 *   --pink      → cyan home         (#0ea5e9)
 *   --amber     → ámbar warning     (#f59e0b)  (semántico, sin cambio)
 *   --green     → verde success     (#10b981)  (semántico, sin cambio)
 *   --blue      → azul              (#3b82f6)  (sin cambio)
 */
/* ===== Variables ===== */
    :root {
        --amber: #f59e0b;
        --amber-light: #fbbf24;
        --bg-amber-soft: #fffbeb;
        --bg-card: #ffffff;
        --bg-green-soft: #f0fdf4;
        --bg-pink-soft: #f0f9ff;
        --bg-primary: #f8fafc;
        --bg-teal-soft: #eff6ff;
        --bg-violet-soft: #eff6ff;
        --blue: #3b82f6;
        --border-color: #e2e8f0;
        --green: #10b981;
        --green-light: #34d399;
        --pink: #0ea5e9;
        --pink-light: #38bdf8;
        --teal: #0056a3;
        --teal-light: #2074bd;
        --text-primary: #1e293b;
        --text-secondary: #64748b;
        --violet: #2563eb;
        --violet-light: #60a5fa;
    }

/* ===== Hero Section ===== */
.detail-hero {
    background: linear-gradient(135deg, var(--teal) 0%, var(--violet) 50%, var(--pink) 100%);
    color: white;
    padding: 50px 0;
    margin-bottom: 30px;
    position: relative;
    overflow: hidden;
}

.detail-hero::before {
    content: "";
    position: absolute;
    top: -50%;
    right: -20%;
    width: 70%;
    height: 200%;
    background: radial-gradient(circle, rgba(255,255,255,0.1) 0%, transparent 50%);
    animation: float 15s ease-in-out infinite;
}

@keyframes float {
    0%, 100% { transform: translate(0, 0); }
    50% { transform: translate(20px, -20px); }
}

.back-link {
    color: rgba(255,255,255,0.85);
    text-decoration: none;
    margin-bottom: 15px;
    display: inline-flex;
    align-items: center;
    gap: 8px;
    font-weight: 500;
    transition: all 0.3s;
    position: relative;
    z-index: 2;
}

.back-link:hover {
    color: white;
    transform: translateX(-5px);
}

.detail-hero h1 {
    font-size: 2.2rem;
    font-weight: 800;
    margin-bottom: 15px;
    position: relative;
    z-index: 2;
}

/* ===== Prognosis Badges ===== */
.prognosis-badge-lg {
    padding: 10px 24px;
    border-radius: 30px;
    font-weight: 700;
    font-size: 0.95rem;
    text-transform: uppercase;
    letter-spacing: 0.5px;
    display: inline-block;
}

.prognosis-good { 
    background: rgba(16, 185, 129, 0.2); 
    border: 2px solid var(--green);
    color: var(--bg-green-soft);
}
.prognosis-intermediate { 
    background: rgba(245, 158, 11, 0.2); 
    border: 2px solid var(--amber);
    color: var(--bg-amber-soft);
}
.prognosis-poor { 
    background: rgba(14, 165, 233, 0.2); 
    border: 2px solid var(--pink);
    color: var(--bg-pink-soft);
}

/* ===== Detail Meta ===== */
.detail-meta {
    display: flex;
    gap: 25px;
    flex-wrap: wrap;
    margin-top: 20px;
    position: relative;
    z-index: 2;
}

.meta-item {
    display: inline-flex;
    align-items: center;
    gap: 8px;
    opacity: 0.95;
    background: rgba(255,255,255,0.1);
    padding: 8px 16px;
    border-radius: 25px;
    backdrop-filter: blur(10px);
    font-weight: 500;
}

.meta-item i {
    font-size: 1.1rem;
}

/* ===== Edit Button ===== */
.btn-hero-edit {
    background: rgba(255,255,255,0.15);
    border: 2px solid rgba(255,255,255,0.3);
    color: white;
    border-radius: 12px;
    padding: 10px 20px;
    font-weight: 600;
    transition: all 0.3s;
    backdrop-filter: blur(10px);
}

.btn-hero-edit:hover {
    background: white;
    color: var(--violet);
    border-color: white;
}

/* ===== Info Cards ===== */
.info-card {
    background: var(--bg-card);
    border: 2px solid var(--border-color);
    border-radius: 20px;
    padding: 25px;
    margin-bottom: 25px;
    transition: all 0.3s;
}

.info-card:hover {
    border-color: var(--violet);
    box-shadow: 0 10px 30px rgba(37, 99, 235, 0.1);
}

.info-card.h-100 {
    height: 100%;
    margin-bottom: 0;
}

.info-card h5 {
    color: var(--text-primary);
    font-weight: 700;
    margin-bottom: 20px;
    padding-bottom: 12px;
    border-bottom: 3px solid transparent;
    border-image: linear-gradient(90deg, var(--teal), var(--violet), var(--pink)) 1;
    display: flex;
    align-items: center;
    gap: 10px;
}

.info-card h5 i {
    color: var(--violet);
}

/* ===== Gene Badges ===== */
.gene-badge-lg {
    display: inline-block;
    background: linear-gradient(135deg, var(--violet), var(--violet-light));
    color: white;
    padding: 10px 20px;
    border-radius: 25px;
    margin: 5px;
    font-weight: 600;
    box-shadow: 0 4px 15px rgba(37, 99, 235, 0.3);
    transition: all 0.3s;
}

.gene-badge-lg:hover {
    transform: translateY(-2px);
    box-shadow: 0 6px 20px rgba(37, 99, 235, 0.4);
}

/* ===== Details Table ===== */
.info-card .table {
    margin-top: 20px;
    border-radius: 12px;
    overflow: hidden;
}

.info-card .table thead {
    background: linear-gradient(135deg, var(--teal), var(--violet));
    color: white;
}

.info-card .table thead th {
    border: none;
    padding: 12px 15px;
    font-weight: 600;
}

.info-card .table tbody tr {
    transition: all 0.2s;
}

.info-card .table tbody tr:hover {
    background: linear-gradient(135deg, var(--bg-teal-soft), var(--bg-violet-soft));
}

.info-card .table td {
    padding: 12px 15px;
    border-color: var(--border-color);
}

/* ===== Treatment Items ===== */
.treatment-item {
    display: flex;
    align-items: center;
    padding: 14px 18px;
    background: var(--bg-primary);
    border-radius: 12px;
    margin-bottom: 10px;
    transition: all 0.3s;
    border: 2px solid transparent;
}

.treatment-item:hover {
    transform: translateX(5px);
}

.treatment-item.recommended {
    background: linear-gradient(135deg, var(--bg-green-soft), #a7f3d0);
    border-left: 4px solid var(--green);
}

.treatment-item.recommended:hover {
    border-color: var(--green);
}

.treatment-item.avoid {
    background: linear-gradient(135deg, var(--bg-pink-soft), #bae6fd);
    border-left: 4px solid var(--pink);
}

.treatment-item.avoid:hover {
    border-color: var(--pink);
}

.treatment-item i {
    margin-right: 12px;
    font-size: 1.3rem;
}

/* ===== Stat Boxes ===== */
.stat-box {
    text-align: center;
    padding: 25px 15px;
    background: linear-gradient(135deg, var(--bg-teal-soft), var(--bg-violet-soft));
    border-radius: 16px;
    border: 2px solid var(--border-color);
    transition: all 0.3s;
}

.stat-box:hover {
    border-color: var(--violet);
    transform: translateY(-3px);
}

.stat-box .value {
    font-size: 2.2rem;
    font-weight: 800;
    background: linear-gradient(135deg, var(--teal), var(--violet));
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}

.stat-box .label {
    color: var(--text-secondary);
    font-size: 0.85rem;
    font-weight: 600;
    margin-top: 5px;
}

/* ===== References ===== */
.references-text {
    font-style: italic;
    color: var(--text-secondary);
    background: linear-gradient(135deg, var(--bg-teal-soft), var(--bg-violet-soft));
    padding: 18px;
    border-radius: 12px;
    border-left: 4px solid var(--violet);
    line-height: 1.7;
}

/* ===== Clinical Notes ===== */
.clinical-notes {
    background: linear-gradient(135deg, var(--bg-amber-soft), #fde68a);
    padding: 20px;
    border-radius: 12px;
    border-left: 4px solid var(--amber);
    color: #92400e;
    line-height: 1.7;
}

/* ===== Actionable Banner ===== */
.actionable-banner {
    background: linear-gradient(135deg, var(--teal), var(--teal-light));
    color: white;
    padding: 20px 30px;
    border-radius: 16px;
    display: flex;
    align-items: center;
    gap: 20px;
    margin-bottom: 30px;
    box-shadow: 0 8px 30px rgba(0, 86, 163, 0.3);
}

.actionable-banner i {
    font-size: 2.5rem;
    opacity: 0.9;
}

.actionable-banner strong {
    font-size: 1.1rem;
}

.actionable-banner small {
    opacity: 0.9;
}

/* ===== Related Combinations ===== */
.info-card ul.list-unstyled li {
    margin-bottom: 12px;
    padding: 10px 15px;
    background: var(--bg-primary);
    border-radius: 10px;
    transition: all 0.3s;
}

.info-card ul.list-unstyled li:hover {
    background: linear-gradient(135deg, var(--bg-teal-soft), var(--bg-violet-soft));
    transform: translateX(5px);
}

.info-card ul.list-unstyled li a {
    color: var(--text-primary);
    font-weight: 600;
    transition: color 0.3s;
}

.info-card ul.list-unstyled li:hover a {
    color: var(--violet);
}

.badge.bg-success {
    background: linear-gradient(135deg, var(--green), var(--green-light)) !important;
}

.badge.bg-warning {
    background: linear-gradient(135deg, var(--amber), var(--amber-light)) !important;
    color: #78350f !important;
}

.badge.bg-danger {
    background: linear-gradient(135deg, var(--pink), var(--pink-light)) !important;
}

/* ===== Disclaimer ===== */
.alert-info {
    background: linear-gradient(135deg, #dbeafe, #e0e7ff);
    border: 2px solid var(--blue);
    border-radius: 16px;
    color: #1e40af;
    padding: 20px 25px;
}

.alert-info i {
    font-size: 1.2rem;
    margin-right: 10px;
}

/* ===== Responsive ===== */
@media (max-width: 768px) {
    .detail-hero h1 {
        font-size: 1.7rem;
    }
    
    .detail-meta {
        gap: 10px;
    }
    
    .meta-item {
        padding: 6px 12px;
        font-size: 0.85rem;
    }
    
    .actionable-banner {
        flex-direction: column;
        text-align: center;
    }
}