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NCT00003594

Quimioterapia combinada en el tratamiento de pacientes con cáncer colorrectal avanzado.

Archived Fase 3

Descripción

JUSTIFICACIÓN: Los fármacos utilizados en la quimioterapia actúan de diferentes maneras para impedir que las células tumorales se dividan, lo que detiene su crecimiento o provoca su muerte. La combinación de más de un fármaco puede destruir un mayor número de células tumorales. Aún no se sabe cuál es el régimen de quimioterapia combinada más eficaz para tratar el cáncer colorrectal avanzado.

OBJETIVO: Ensayo aleatorizado de fase III para comparar la eficacia de varios regímenes de quimioterapia combinada en el tratamiento de pacientes con cáncer colorrectal avanzado, recurrente o metastásico que no puede ser tratado con cirugía o radioterapia.

Evidencia de la diana molecular en cáncer colorrectal

Aún no hay evidencia documentada en nuestra base para la diana o el fármaco de este ensayo. Esta sección crece a medida que se procesan nuevas publicaciones.

Criterios de Elegibilidad

CARACTERÍSTICAS DE LA ENFERMEDAD:

  • Adenocarcinoma colorrectal localmente avanzado, localmente recurrente o metastásico, confirmado histológica o citológicamente, que no pueda ser curado mediante cirugía o radioterapia.
  • Se exime el requisito histológico o citológico en pacientes que desarrollaron evidencia radiológica o clínica de cáncer metastásico después de una resección quirúrgica previa, a menos que:
  • Haya transcurrido más de 5 años desde la cirugía primaria O
  • El cáncer primario fue de estadio I o II
  • La localización de la lesión primaria debe estar confirmada o haber estado confirmada endoscópicamente, radiológicamente o quirúrgicamente en el intestino grueso.
  • Enfermedad medible o evaluable.
  • Sin metástasis en el SNC o meningitis carcinomatosa.

CARACTERÍSTICAS DEL PACIENTE:

Edad:

  • 18 años o más.

Estado funcional:

  • ECOG 0-2.

Esperanza de vida:

  • Al menos 12 semanas.

Hematopoyético:

  • Recuento absoluto de granulocitos de al menos 1.500/mm³.
  • Recuento de plaquetas de al menos 100.000/mm³.
  • Hemoglobina de al menos 9,0 g/dL (se permite la transfusión).

Hepático:

  • Bilirrubina no mayor de 1,5 mg/dL.
  • AST no mayor de 5 veces el límite superior de la normalidad (LSN).
  • Fosfatasa alcalina no mayor de 5 veces el LSN.

Renal:

  • Creatinina no mayor de 1,5 veces el LSN.

Cardiovascular:

  • Sin hipertensión no controlada.
  • Sin angina inestable.
  • Sin insuficiencia cardíaca congestiva sintomática.
  • Sin infarto de miocardio en los últimos 6 meses.
  • Sin arritmia grave no controlada.
  • Sin enfermedad cardíaca de la clase III o IV de la Asociación Cardíaca de Nueva York.

Pulmonar:

  • Sin neumonía intersticial o fibrosis intersticial pulmonar extensa y sintomática.
  • Sin derrame pleural o ascitis que causen compromiso respiratorio (disnea de grado 2 o superior).

Otros:

  • No embarazada ni en período de lactancia.
  • Prueba de embarazo negativa.
  • Las pacientes fértiles deben utilizar métodos anticonceptivos eficaces.
  • Sin infección activa o no controlada.
  • Sin neuropatía periférica sensorial sintomática.
  • Sin alergia conocida a compuestos de platino.
  • Sin antecedentes de hemorragia gastrointestinal, a menos que el médico responsable del estudio determine que es aceptable.
  • Sin otra neoplasia previa o concurrente en los últimos 3 años, excepto cáncer de piel no melanoma, carcinoma in situ del cuello uterino u otro tumor maligno resecado con menos del 10% de probabilidad de recurrencia tumoral en 3 años desde el diagnóstico.
  • Sin afecciones médicas o psiquiátricas que impidan la participación en el estudio.
  • Sin trastornos del colon o del intestino delgado con síntomas no controlados de más de 3 deposiciones blandas al día.
  • Se permite la colostomía o ileostomía a discreción del investigador.

TERAPIA CONCURRENTE PREVIA:

Terapia biológica:

  • Se permite la inmunoterapia adyuvante previa para la enfermedad en estadio II-IV resecada, si la terapia adyuvante finalizó al menos 1 año antes de la documentación de la enfermedad recurrente.
  • No se permite el sargramostim (GM-CSF) de forma concurrente.

Quimioterapia:

  • No se permite la quimioterapia previa para el cáncer colorrectal avanzado.
  • No se permite la quimioterapia adyuvante estándar previa para el cáncer de recto.
  • Se permite la fluorouracilo adyuvante previa para la enfermedad en estadio II-IV resecada, si la terapia adyuvante finalizó al menos 1 año antes de la documentación de la enfermedad recurrente.

Radioterapia:

  • Consulte las Características de la enfermedad.
  • Al menos 4 semanas desde la radioterapia mayor previa (por ejemplo, radioterapia paliativa torácica o ósea).
  • No se permite la radioterapia previa en más del 15% de la médula ósea.
  • No se permite la radioterapia adyuvante estándar previa para el cáncer de recto.

Cirugía:

  • Consulte las Características de la enfermedad.
  • Al menos 4 semanas desde la cirugía mayor previa (por ejemplo, laparotomía) (2 semanas para cirugía menor) y recuperación.
  • La inserción de un dispositivo de acceso vascular no se considera cirugía mayor ni menor.

Otros:

  • No se permiten otros agentes de investigación de forma concurrente.

Información del Ensayo

NCT00003594
Archived
Fase 3
1691 participantes
Oct 1998

Ubicaciones466

Canada (31)
Lions Gate Hospital
North Vancouver, V7L 2P9
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2
British Columbia Cancer Agency - Centre for the Southern Interior
Kelowna, British Columbia, V1Y 5L3
Nanaimo Cancer Clinic
Nanaimo, British Columbia, V9S 2B7
British Columbia Cancer Agency - Fraser Valley Cancer Centre
Surrey, British Columbia, V3V 1Z2
British Columbia Cancer Agency
Vancouver, British Columbia, V5Z 4E6
British Columbia Cancer Agency - Vancouver Island Cancer Centre
Victoria, British Columbia, V8R 6V5
St. Boniface General Hospital
Winnipeg, Manitoba, R2H 2A6
Nova Scotia Cancer Centre
Halifax, Nova Scotia, B3H 1V7
William Osler Health Centre
Brampton, Ontario, L6W 2Z8
Northeastern Ontario Regional Cancer Centre, Sudbury
Greater Sudbury, Ontario, P3E 5J1
Cancer Care Ontario-London Regional Cancer Centre
London, Ontario, N6A 4L6
Credit Valley Hospital
Mississauga, Ontario, L5M 2N1
Trillium Health Centre
Mississauga, Ontario, L5B 1B8
Southlake Regional Health Centre
Newmarket, Ontario, L3Y 2P9
Peterborough Oncology Clinic
Peterborough, Ontario, K9H 7B6
Algoma District Medical Group
Sault Ste. Marie, Ontario, P6B 1Y5
Hotel Dieu Health Sciences Hospital - Niagara
St. Catharines, Ontario, L2R 5K3
Northwestern Ontario Regional Cancer Centre, Thunder Bay
Thunder Bay, Ontario, P7A 7T1
Mount Sinai Hospital - Toronto
Toronto, Ontario, M5G 1X5
Saint Joseph's Health Centre - Toronto
Toronto, Ontario, M6R 1B5
Humber River Regional Hospital
Weston, Ontario, M9N 1N8
Queen Elizabeth Hospital, PEI
Charlottetown, Prince Edward Island, C1A 8T5
Hopital Charles Lemoyne
Greenfield Park, Quebec, J4V 2H1
Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, H2L-4M1
CHUM Hopital Saint-Luc
Montreal, Quebec, H2X 3J4
Maisonneuve-Rosemont Hospital
Montreal, Quebec, H1T 2M4
L'Hopital Laval
Ste-Foy, Quebec, G1V 4G5
Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1
Pasqua Hospital
Regina, Saskatchewan, S4T 7T1
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4
Puerto Rico (3)
Centro Mamografia Hospital Oncologico
Hato Rey, 00919-1811
San Juan City Hospital
San Juan, 00936-7344
Veterans Affairs Medical Center - San Juan
San Juan, 00927-5800
South Africa (2)
Medical Oncology Centre of Rosebank
Johannesburg, 2193
Pretoria Academic Hospitals
Pretoria, 0001
United States (430)
Veterans Affairs Medical Center - Birmingham
Birmingham, Alabama, 35233-1996
MBCCOP - Gulf Coast
Mobile, Alabama, 36688
CCOP - Greater Phoenix
Phoenix, Arizona, 85006-2726
Mayo Clinic Hospital
Phoenix, Arizona, 85054-4502
Veterans Affairs Medical Center - Phoenix (Hayden)
Phoenix, Arizona, 85012
Mayo Clinic Scottsdale
Scottsdale, Arizona, 85259
Arizona Cancer Center
Tucson, Arizona, 85724
Veterans Affairs Medical Center - Tucson
Tucson, Arizona, 85723
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
Veterans Affairs Medical Center - Little Rock (McClellan)
Little Rock, Arkansas, 72205
Cancer Center and Beckman Research Institute, City of Hope
Duarte, California, 91010-3000
University of California San Diego Cancer Center
La Jolla, California, 92093-0658
Veterans Affairs Medical Center - Long Beach
Long Beach, California, 90822
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, 90033-0804
Veterans Affairs Medical Center - West Los Angeles
Los Angeles, California, 90073
Veterans Affairs Outpatient Clinic - Martinez
Martinez, California, 94553
Community Hospital of the Monterey Peninsula
Monterey, California, 93940
CCOP - Bay Area Tumor Institute
Oakland, California, 94609-3305
Chao Family Comprehensive Cancer Center
Orange, California, 92868
Veterans Affairs Medical Center - Palo Alto
Palo Alto, California, 94304
University of California Davis Medical Center
Sacramento, California, 95817
UCSF Cancer Center and Cancer Research Institute
San Francisco, California, 94143-0128
Veterans Affairs Medical Center - San Francisco
San Francisco, California, 94121
CCOP - Santa Rosa Memorial Hospital
Santa Rosa, California, 95403
Stanford University Medical Center
Stanford, California, 94305-5408
David Grant Medical Center
Travis Air Force Base, California, 94535
Columbia Medical Center of Aurora North Campus
Aurora, Colorado, 80011
Penrose Cancer Center
Colorado Springs, Colorado, 80933
CCOP - Colorado Cancer Research Program, Inc.
Denver, Colorado, 80209-5031
HealthOne Rose Medical Center
Denver, Colorado, 80220
Porter Adventist Hospital
Denver, Colorado, 80210
Presbyterian-St Luke's Medical Center
Denver, Colorado, 80218
St. Joseph Hospital
Denver, Colorado, 80218
University of Colorado Cancer Center
Denver, Colorado, 80010
Veterans Affairs Medical Center - Denver
Denver, Colorado, 80220
Swedish Medical Center
Englewood, Colorado, 80110
Poudre Valley Hospital
Fort Collins, Colorado, 80524
Poudre Valley Radiation Oncology
Fort Collins, Colorado, 80528
Rocky Mountain Cancer Centers - Northern Colorado
Fort Collins, Colorado, 80524-4038
St. Mary-Corwin Regional Medical Center
Pueblo, Colorado, 81004
Bristol Hospital
Bristol, Connecticut, 06011-0977
University of Connecticut Health Center
Farmington, Connecticut, 06360-7106
St. Francis Hospital and Medical Center
Hartford, Connecticut, 06105
New Britain General Hospital
New Britain, Connecticut, 06050
Lawrence and Memorial Hospital
New London, Connecticut, 06320
William W. Backus Hospital
Norwich, Connecticut, 06360
Northwestern Connecticut Oncology-Hematology Associates
Torrington, Connecticut, 06790
CCOP - Christiana Care Health Services
Wilmington, Delaware, 19899
Walter Reed Army Medical Center
Washington D.C., District of Columbia, 20307-5000
University of Florida - Gainesville
Gainesville, Florida, 32610-0277
Baptist Regional Cancer Institute - Jacksonville
Jacksonville, Florida, 32207
Mayo Clinic
Jacksonville, Florida, 32224
University of Florida Health Science Center - Jacksonville
Jacksonville, Florida, 32209
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, 33140
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612-9497
CCOP - Atlanta Regional
Atlanta, Georgia, 30342-1701
Emory University Hospital - Atlanta
Atlanta, Georgia, 30322
Grady Memorial Hospital
Atlanta, Georgia, 30335
Veterans Affairs Medical Center - Atlanta (Decatur)
Decatur, Georgia, 30033
Dwight David Eisenhower Army Medical Center
Fort Gordon, Georgia, 30905-5650
Cancer Research Center of Hawaii
Honolulu, Hawaii, 96813
BroMenn Lifecare Center
Bloomington, Illinois, 61701-3081
St. Joseph's Hospital Medical Center
Bloomington, Illinois, 61701
Graham Hospital Association
Canton, Illinois, 61520
Memorial Hospital
Carthage, Illinois, 62321
Hematology Oncology Associates of Illinois - Lake Shore Dr
Chicago, Illinois, 60611
Hematology-Oncology Associates of Illinois
Chicago, Illinois, 60611-2998
Mercy Hospital and Medical Center
Chicago, Illinois, 60616
Robert H. Lurie Comprehensive Cancer Center, Northwestern University
Chicago, Illinois, 60611-3013
University of Chicago Cancer Research Center
Chicago, Illinois, 60637-1470
Veterans Affairs Medical Center - Chicago (Westside Hospital)
Chicago, Illinois, 60612
Veterans Affairs Medical Center - Lakeside Chicago
Chicago, Illinois, 60611
CCOP - Central Illinois
Decatur, Illinois, 62526
Holy Family Medical Center
Des Plaines, Illinois, 60016
St. Anthony's Memorial Hospital
Effingham, Illinois, 62401
Northwest Oncology and Hematology, S.C.
Elk Grove Village, Illinois, 60007
Eureka Hospital
Eureka, Illinois, 61530
CCOP - Evanston
Evanston, Illinois, 60201
Galesburg Clinic
Galesburg, Illinois, 61401
Galesburg Cottage Hospital
Galesburg, Illinois, 61402
InterCommunity Cancer Center of Western Illinois
Galesburg, Illinois, 61401
Glenbrook Hospital
Glenview, Illinois, 60025
Ingalls Memorial Hospital
Harvey, Illinois, 60426
Mason District Hospital
Havana, Illinois, 62644
Hematology Oncology Associates of Illinois-Highland Park
Highland Park, Illinois, 60035
Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
Hines, Illinois, 60141
Hinsdale Hematology Oncology Associates
Hinsdale, Illinois, 60521
Hopedale Medical Complex Hospital
Hopedale, Illinois, 61747
Joliet Oncology/Hematology Associates, Ltd.
Joliet, Illinois, 60435
Saint Joseph Medical Center
Joliet, Illinois, 60435
Silver Cross Hospital
Joliet, Illinois, 60432
Kewanee Hospital
Kewanee, Illinois, 61443
Deerpath Medical Associates
Lake Forest, Illinois, 60045
North Shore Oncology Hematology Associates
Libertyville, Illinois, 60048
McDonough District Hospital
Macomb, Illinois, 61455
Loyola University Medical Center
Maywood, Illinois, 60153
Hematology/Oncology Associates of Illinois, LLC
Melrose Park, Illinois, 60160
Mendota Community Hospital
Mendota, Illinois, 61342
Trinity Medical Center
Moline, Illinois, 61265-1291
Morris Hospital
Morris, Illinois, 60450
BroMenn Regional Medical Center
Normal, Illinois, 61761
Community Cancer Center
Normal, Illinois, 61761
Hematology Oncology Associates of Illinois, LLC
Oak Park, Illinois, 60304
Community Hospital of Ottawa
Ottawa, Illinois, 61350
Pekin Hospital
Pekin, Illinois, 61554
Affiliated Urology Specialists
Peoria, Illinois, 61603
Illinois Oncology Research Association
Peoria, Illinois, 61602
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
Midwest Radiation Oncology Physicians
Peoria, Illinois, 61636
Midwest Urological Group
Peoria, Illinois, 61603
Oncology/Hematology Associates of Central Illinois, P.C.
Peoria, Illinois, 61602
Peoria Urological Associates
Peoria, Illinois, 61614
Proctor Hospital
Peoria, Illinois, 61614
St. Francis Medical Center
Peoria, Illinois, 61637
Illinois Valley Community Hospital
Peru, Illinois, 61354
St. James Hospital
Pontiac, Illinois, 61764
Perry Memorial Hospital
Princeton, Illinois, 61356
Trinity Medical Center
Rock Island, Illinois, 61201
Swedish-American Health System
Rockford, Illinois, 61104-2315
Sarah D. Culbertson Memorial Hospital
Rushville, Illinois, 62681
Edward H. Kaplan MD and Associates
Skokie, Illinois, 60076
Hematology Oncology Associates - Skokie
Skokie, Illinois, 60076
Midwest Cancer Research Group, Inc.
Skokie, Illinois, 60077
St. Margaret's Hospital
Spring Valley, Illinois, 61362
Valley Cancer Center
Spring Valley, Illinois, 61362
Carle Cancer Center
Urbana, Illinois, 61801
Carle Foundation Hospital
Urbana, Illinois, 61801
Therapy Associates Hematology/Oncology
Evansville, Indiana, 47715
Oncology Institute of Greater Lafayette
Lafayette, Indiana, 47904
McFarland Clinic, P.C.
Ames, Iowa, 50010
William R. Bliss Cancer Center
Ames, Iowa, 50010
Hematology Oncology Associates of the Quad Cities
Bettendorf, Iowa, 52722
Saint Anthony Regional Hospital
Carroll, Iowa, 51401
Cedar Rapids Oncology Associates
Cedar Rapids, Iowa, 52403
Mercy Medical Center
Cedar Rapids, Iowa, 52403
St. Luke's Hospital
Cedar Rapids, Iowa, 52406
Alegent Health Southwest Iowa Medical Center
Council Bluffs, Iowa, 51503
Des Moines General Hospital
Des Moines, Iowa, 50309
Iowa Lutheran Hospital
Des Moines, Iowa, 50316-2392
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
Medical Oncology and Hematology Associates
Des Moines, Iowa, 50309
Medical Oncology and Hematology Associates
Des Moines, Iowa, 50314
Mercy Hospital Medical Center
Des Moines, Iowa, 50314
Holden Comprehensive Cancer Center at The University of Iowa
Iowa City, Iowa, 52242-1009
Mercy Cancer Center
Mason City, Iowa, 50401
Community Memorial Hospital
Missouri Valley, Iowa, 51555-1199
Burgess Health Center
Onawa, Iowa, 51040
Oncology & Hematology of Ottumwa, PC
Ottumwa, Iowa, 52501
Ottumwa Regional Health Center
Ottumwa, Iowa, 52501
Mercy Medical Center - Sioux City
Sioux City, Iowa, 51101
Siouxland Hematology-Oncology
Sioux City, Iowa, 51101-1733
St. Luke's Regional Medical Center
Sioux City, Iowa, 51104
Cancer Center of Kansas - Arkansas City
Arkansas City, Kansas, 67005
Cancer Center of Kansas - Chanute
Chanute, Kansas, 66720
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, 67801
Radiation Oncology Center
Dodge City, Kansas, 67801
Halstead Cancer Center of Kansas
Halstead, Kansas, 67056
University of Kansas Medical Center
Kansas City, Kansas, 66160-7357
Cancer Center of Kansas - Kingman
Kingman, Kansas, 67068
Liberal Cancer Center of Kansas
Liberal, Kansas, 67901
Cancer Center of Kansas - Newton
Newton, Kansas, 67114
Pratt Cancer Center of Kansas
Pratt, Kansas, 67124
Cancer Center of Kansas - Salina
Salina, Kansas, 67401
Cancer Center of Kansas - Wellington
Wellington, Kansas, 67152
Associates in Women's Health - Wichita
Wichita, Kansas, 67208
Cancer Center of Kansas - Wichita
Wichita, Kansas, 67214
CCOP - Wichita
Wichita, Kansas, 67214-3882
Veterans Affairs Medical Center - Wichita
Wichita, Kansas, 67218
Via Christi Regional Medical Center
Wichita, Kansas, 67214
Wichita Clinic Cancer Medicine Associates, P.A.
Wichita, Kansas, 67208
Cancer Center of Kansas - Winfield
Winfield, Kansas, 67156
Albert B. Chandler Medical Center, University of Kentucky
Lexington, Kentucky, 40536-0084
Veterans Affairs Medical Center - Lexington
Lexington, Kentucky, 40511-1093
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112
Tulane University School of Medicine
New Orleans, Louisiana, 70112
Louisiana State University Health Sciences Center - Shreveport
Shreveport, Louisiana, 71130-3932
Veterans Affairs Medical Center - Shreveport
Shreveport, Louisiana, 71130
Veterans Affairs Medical Center - Togus
Togus, Maine, 04330
Anne Arundel Medical Center
Annapolis, Maryland, 21401
Boston Medical Center
Boston, Massachusetts, 02118
Dana-Farber Cancer Institute
Boston, Massachusetts, 02115
New England Medical Center Hospital
Boston, Massachusetts, 02111
Faulkner Hospital
Jamaica Plain, Massachusetts, 02130
Veterans Affairs Medical Center - Boston (Jamaica Plain)
Jamaica Plain, Massachusetts, 02130
Lawrence Memorial Hospital of Medford/Hallmark Health Systems
Medford, Massachusetts, 02155
Morton Hospital & Medical Center
Taunton, Massachusetts, 02780
University of Massachusetts Memorial Medical Center
Worcester, Massachusetts, 01655
Bixby Medical Center
Adrian, Michigan, 49221
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, 48106
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0752
Veterans Affairs Medical Center - Ann Arbor
Ann Arbor, Michigan, 48105
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201-1379
Henry Ford Hospital
Detroit, Michigan, 48202
St. John Hospital and Medical Center
Detroit, Michigan, 48236
Veterans Affairs Medical Center - Detroit
Detroit, Michigan, 48201-1932
Genesee Regional Medical Center
Flint, Michigan, 48503
CCOP - Grand Rapids Clinical Oncology Program
Grand Rapids, Michigan, 49503
Borgess Medical Center
Kalamazoo, Michigan, 49048-1666
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
Sparrow Regional Cancer Center
Lansing, Michigan, 48909
Office of E. Michael Lodish
Madison Heights, Michigan, 48071-3457
Community Cancer Center of Monroe
Monroe, Michigan, 48162
Balcueva Clinic
Saginaw, Michigan, 48602
St. Mary's Medical Center
Saginaw, Michigan, 48601
Providence Hospital - Southfield
Southfield, Michigan, 48075-9975
St. John Macomb Hospital
Warren, Michigan, 48093-3494
Alexandria Clinic
Alexandria, Minnesota, 56308
Alexandria Radiation Oncology
Alexandria, Minnesota, 56308
Brainerd Medical Center
Brainerd, Minnesota, 56401
St. Joseph's Medical Center
Brainerd, Minnesota, 56401
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
Mercy Hospital
Coon Rapids, Minnesota, 55433
Duluth Clinic
Duluth, Minnesota, 55805
Miller-Dwan Medical Center
Duluth, Minnesota, 55805
St. Mary's/Duluth Clinic Health System
Duluth, Minnesota, 55805
Fairview-Southdale Hospital
Edina, Minnesota, 55435
Fergus Falls Medical Group
Fergus Falls, Minnesota, 56537
Mercy/Unity Hospitals
Fridley, Minnesota, 55432
Central Mesabi Medical Center
Hibbing, Minnesota, 55746
Duluth Clinic - Hibbing
Hibbing, Minnesota, 55746
Radiation Therapy Center
Hibbing, Minnesota, 55746
Hutchinson Area Health Care
Hutchinson, Minnesota, 55350
Meeker County Memorial Hospital
Litchfield, Minnesota, 55355
St. John's Hospital
Maplewood, Minnesota, 55109
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
Fairview University Medical Center - Riverside Campus
Minneapolis, Minnesota, 55454-1395
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, 55415
North Memorial Research Center
Minneapolis, Minnesota, 55442-2900
University of Minnesota Cancer Center
Minneapolis, Minnesota, 55455
Veterans Affairs Medical Center - Minneapolis
Minneapolis, Minnesota, 55417
Virginia Piper Cancer Institute
Minneapolis, Minnesota, 55407
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905
CentraCare Health Plaza
Saint Cloud, Minnesota, 56303
St. Cloud Hospital
Saint Cloud, Minnesota, 56303
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, 55416
Park Nicollet Clinic
Saint Louis Park, Minnesota, 55416
Healtheast Cancer Care
Saint Paul, Minnesota, 55102
Regions Hospital
Saint Paul, Minnesota, 55101
United Hospital
Saint Paul, Minnesota, 55102
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
Ridgeview Medical Center
Waconia, Minnesota, 55387
Rice Memorial Hospital
Willmar, Minnesota, 56201
Veterans Affairs Medical Center - Biloxi
Biloxi, Mississippi, 39531-2410
University of Mississippi Medical Center
Jackson, Mississippi, 39216-4505
Veterans Affairs Medical Center - Jackson
Jackson, Mississippi, 39216
Keesler Medical Center - Keesler AFB
Keesler Air Force Base, Mississippi, 39534-2576
Ellis Fischel Cancer Center - Columbia
Columbia, Missouri, 65203
Veterans Affairs Medical Center - Columbia (Truman Memorial)
Columbia, Missouri, 65201
CCOP - Kansas City
Kansas City, Missouri, 64131
Veterans Affairs Medical Center - Kansas City
Kansas City, Missouri, 64128
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65807
Barnes-Jewish Hospital
St Louis, Missouri, 63110
CCOP - St. Louis-Cape Girardeau
St Louis, Missouri, 63141
St. Louis University Health Sciences Center
St Louis, Missouri, 63110-0250
CCOP - Montana Cancer Consortium
Billings, Montana, 59101
Fremont Area Medical Center
Fremont, Nebraska, 68025-2387
Bryan LGH Medical Center
Lincoln, Nebraska, 68502-3780
Bryan LGH Medical Center East
Lincoln, Nebraska, 68506
Office of Susan Hansen, M.D.
Lincoln, Nebraska, 68506
Prairie View Clinic
Lincoln, Nebraska, 68506-5247
Southeast Nebraska Hematology
Lincoln, Nebraska, 68516
Southeast Nebreska Hematology-Oncology Consultants, PC
Lincoln, Nebraska, 68516
St. Elizabeth Regional Medical Center
Lincoln, Nebraska, 68510
Wedgewood Medical Center
Lincoln, Nebraska, 68510
Williamsburg Radiation Oncology Center
Lincoln, Nebraska, 68516
Alegent Health - Immanuel Medical Center
Omaha, Nebraska, 68122
Bergan Mercy Medical Center
Omaha, Nebraska, 68124
Creighton University Cancer Center
Omaha, Nebraska, 68131-2197
Oncology Hematology West, P.C.
Omaha, Nebraska, 68114
St. Joseph Hospital
Omaha, Nebraska, 68131-2197
University of Nebraska Medical Center
Omaha, Nebraska, 68198-3330
Veterans Affairs Medical Center - Omaha
Omaha, Nebraska, 68105
Alegent Health-Midlands Community Hospital
Papillion, Nebraska, 68046-4194
CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, 89106
Norris Cotton Cancer Center
Lebanon, New Hampshire, 03756-0002
Center for Cancer And Hematologic Disease
Cherry Hill, New Jersey, 08046
Trinitas Hospital - Jersey Street Campus
Elizabeth, New Jersey, 07201
Hunterdon Regional Cancer Center
Flemington, New Jersey, 08822
South Jersey Regional Cancer Center
Millville, New Jersey, 08332
Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County
Mount Holly, New Jersey, 08060
Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
Riverview Medical Center - Booker Cancer Center
Red Bank, New Jersey, 07701
St. Francis Medical Center
Trenton, New Jersey, 08629
Southern Oncology-Hematology Associates, P.A.
Vineland, New Jersey, 08360
Comprehensive Cancer and Hematology Associates
Voorhees Township, New Jersey, 08043
Burlington County Hematology Oncology Association, P.A.
Willingboro, New Jersey, 08046
MBCCOP - University of New Mexico HSC
Albuquerque, New Mexico, 87131
Veterans Affairs Medical Center - Albuquerque
Albuquerque, New Mexico, 87108-5138
Veterans Affairs Medical Center - Buffalo
Buffalo, New York, 14215
Mary Imogene Bassett Hospital
Cooperstown, New York, 13326
CCOP - North Shore University Hospital
Manhasset, New York, 11030
Schneider Children's Hospital at North Shore
Manhasset, New York, 11030
Herbert Irving Comprehensive Cancer Center
New York, New York, 10032
Memorial Sloan-Kettering Cancer Center
New York, New York, 10021
Mount Sinai Medical Center, NY
New York, New York, 10029
New York Presbyterian Hospital - Cornell Campus
New York, New York, 10021
NYU School of Medicine's Kaplan Comprehensive Cancer Center
New York, New York, 10016
Veterans Affairs Medical Center - New York
New York, New York, 10010
Rochester General Hospital
Rochester, New York, 14621
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York, 13217
State University of New York - Upstate Medical University
Syracuse, New York, 13210
Veterans Affairs Medical Center - Syracuse
Syracuse, New York, 13210
Albert Einstein Comprehensive Cancer Center
The Bronx, New York, 10461
Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina, 27599-7295
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710
Veterans Affairs Medical Center - Durham
Durham, North Carolina, 27705
CCOP - Southeast Cancer Control Consortium
Winston-Salem, North Carolina, 27104-4241
Comprehensive Cancer Center at Wake Forest University
Winston-Salem, North Carolina, 27157-1082
Bismarck Cancer Center
Bismarck, North Dakota, 58501-4445
Medcenter One Health System
Bismarck, North Dakota, 58501
Mid Dakota Clinic, P.C.
Bismarck, North Dakota, 58501
St. Alexius Medical Center
Bismarck, North Dakota, 58502
CCOP - Merit Care Hospital
Fargo, North Dakota, 58122
Meritcare Roger Maris Cancer Center
Fargo, North Dakota, 58122
Altru Cancer Center
Grand Forks, North Dakota, 58206
Altru Health Systems
Grand Forks, North Dakota, 58201
Akron City Hospital
Akron, Ohio, 44309
Wood County Oncology Center
Bowling Green, Ohio, 43402
Aultman Cancer Center
Canton, Ohio, 44710
Mercy Ireland Cancer Center
Canton, Ohio, 44708
Barrett Cancer Center, The University Hospital
Cincinnati, Ohio, 45267-0502
Veterans Affairs Medical Center - Cincinnati
Cincinnati, Ohio, 45220-2288
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195
Ireland Cancer Center
Cleveland, Ohio, 44106-5065
Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio, 43210-1240
CCOP - Columbus
Columbus, Ohio, 43206
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, 45428
Woman Wise Blanchard Valley Regional Health Center
Findlay, Ohio, 45840
Fremont Memorial Hospital
Fremont, Ohio, 43420
Office of Sharon Cole, M.D.
Kenton, Ohio, 43326
CCOP - Dayton
Kettering, Ohio, 45429
Lima Memorial Hospital
Lima, Ohio, 45804
St. Rita's Medical Center
Lima, Ohio, 45801
North West Ohio Oncology Center
Maumee, Ohio, 43537
Saint Luke's Hospital
Maumee, Ohio, 43537
St. Charles Hospital
Oregon, Ohio, 43616
Firelands Regional Medical Center
Sandusky, Ohio, 44870
North Coast Cancer Care, Inc.
Sandusky, Ohio, 44870
Flower Hospital - Pro Medica Health System
Sylvania, Ohio, 43560
Haematology-Oncology Associates, Inc.
Toledo, Ohio, 43623-4474
MCO Cancer Institute
Toledo, Ohio, 43614
Medical College of Ohio Hospital
Toledo, Ohio, 43614-0008
Riverside Hospital
Toledo, Ohio, 43604
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608
Toledo Clinic, Inc.
Toledo, Ohio, 43623
Toledo Hospital
Toledo, Ohio, 43606
Fulton County Health Center
Wauseon, Ohio, 43567
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, 73104
Veterans Affairs Medical Center - Oklahoma City
Oklahoma City, Oklahoma, 73104
CCOP - Oklahoma
Tulsa, Oklahoma, 74136
CCOP - Columbia River Program
Portland, Oregon, 97213
Oregon Cancer Center
Portland, Oregon, 97201-3098
Veterans Affairs Medical Center - Portland
Portland, Oregon, 97207
Lehigh Valley Hospital
Allentown, Pennsylvania, 18103
Muhlenberg Hospital Center
Bethlehem, Pennsylvania, 18017
Marion Community Hospital
Carbondale, Pennsylvania, 18407
Geisinger Medical Center
Danville, Pennsylvania, 17822-2001
Delaware County Memorial Hospital
Drexel Hill, Pennsylvania, 19026
DuBois Regional Medical Center
DuBois, Pennsylvania, 15801-0447
UPMC Horizon
Greenville, Pennsylvania, 16125
Pinnacle Health Hospitals
Harrisburg, Pennsylvania, 17105-8700
Wayne Memorial Hospital
Honesdale, Pennsylvania, 18431-1498
Conemaugh Memorial Hospital
Johnstown, Pennsylvania, 15905
UPCI @ UPMC Lee Hospital
Johnstown, Pennsylvania, 15901
Armstrong County Memorial Hospital
Kittanning, Pennsylvania, 16201-8808
Lancaster General Hospital
Lancaster, Pennsylvania, 17604-3555
Saint Mary Regional Center
Langhorne, Pennsylvania, 19047
Latrobe Area Hospital
Latrobe, Pennsylvania, 15650
Central Pennsylvania Hematology and Medical Oncology Associates
Lemoyne, Pennsylvania, 17043
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, 19141
Hahnemann University Hospital
Philadelphia, Pennsylvania, 19102-1192
University of Pennsylvania Cancer Center
Philadelphia, Pennsylvania, 19104-4283
Magee-Womens Hospital
Pittsburgh, Pennsylvania, 15213-3180
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213
UPMC/Passavant Hospital
Pittsburgh, Pennsylvania, 15237
Pottstown Memorial Regional Cancer Center
Pottstown, Pennsylvania, 19464
Reading Hospital and Medical Center
Reading, Pennsylvania, 19612-6052
Mercy Hospital Cancer Center - Scranton
Scranton, Pennsylvania, 18501
Moses Taylor Hospital
Scranton, Pennsylvania, 18510
Scranton Hematology-Oncology
Scranton, Pennsylvania, 18510
Geisinger Medical Group
State College, Pennsylvania, 16801
Chester County Hospital
West Chester, Pennsylvania, 19380
Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, 18711
Rhode Island Hospital
Providence, Rhode Island, 02903
CCOP - Greenville
Greenville, South Carolina, 29615
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29303
Rapid City Regional Hospital
Rapid City, South Dakota, 57709
Avera Cancer Institute
Sioux Falls, South Dakota, 57105
Avera McKennan Hospital and University Health Center
Sioux Falls, South Dakota, 57105-1080
Sioux Valley Clinic
Sioux Falls, South Dakota, 57104
Sioux Valley Hospital
Sioux Falls, South Dakota, 57117
University of Tennessee, Memphis Cancer Center
Memphis, Tennessee, 38103
Veterans Affairs Medical Center - Memphis
Memphis, Tennessee, 38104
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234
University of Texas Medical Branch
Galveston, Texas, 77555-0209
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78284-7811
Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio, Texas, 78284
CCOP - Scott and White Hospital
Temple, Texas, 76508
Veterans Affairs Medical Center - Temple
Temple, Texas, 76504
Huntsman Cancer Institute
Salt Lake City, Utah, 84112
Veterans Affairs Medical Center - Salt Lake City
Salt Lake City, Utah, 84148
Vermont Cancer Center
Burlington, Vermont, 05401-3498
Veterans Affairs Medical Center - White River Junction
White River Junction, Vermont, 05009
MBCCOP - Massey Cancer Center
Richmond, Virginia, 23298-0037
Veterans Affairs Medical Center - Richmond
Richmond, Virginia, 23249
CCOP - Virginia Mason Research Center
Seattle, Washington, 98101
Swedish Cancer Institute
Seattle, Washington, 98104
Veterans Affairs Medical Center - Seattle
Seattle, Washington, 98108
CCOP - Northwest
Tacoma, Washington, 98405-0986
Madigan Army Medical Center
Tacoma, Washington, 98431-5000
Fox Valley Hematology and Oncology
Appleton, Wisconsin, 54911
Memorial Medical Center
Ashland, Wisconsin, 54806
Luther Hospital
Eau Claire, Wisconsin, 54703
Midelfort Clinic
Eau Claire, Wisconsin, 54703
St. Vincent Hospital
Green Bay, Wisconsin, 54307-3508
Franciscan Skemp Healthcare
La Crosse, Wisconsin, 54601-4796
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
Dean Medical Center
Madison, Wisconsin, 53715
Meriter Hospital
Madison, Wisconsin, 53715
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, 53792-6164
Veterans Affairs Medical Center - Madison
Madison, Wisconsin, 53705
CCOP - Marshfield Medical Research and Education Foundation
Marshfield, Wisconsin, 54449
Aurora Sinai Samaritan Medical Center
Milwaukee, Wisconsin, 53201-0342
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
Veterans Affairs Medical Center - Milwaukee (Zablocki)
Milwaukee, Wisconsin, 53295
Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188
UW Cancer Center Wausau Hospital
Wausau, Wisconsin, 54401

Fuente Oficial

Ver en ClinicalTrials.gov