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NCT01079780

Irinotecano clorhidrato y cetuximab, con o sin ramucirumab, en el tratamiento de pacientes con cáncer colorrectal avanzado con enfermedad progresiva tras el tratamiento con quimioterapia que contiene bevacizumab.

Archived Fase 2

Descripción

JUSTIFICACIÓN: Los fármacos utilizados en la quimioterapia, como el clorhidrato de irinotecán, actúan de diferentes maneras para detener el crecimiento de las células tumorales, ya sea matando las células o impidiendo que se dividan. Los anticuerpos monoclonales, como el cetuximab y el ramucirumab, pueden bloquear el crecimiento tumoral de diferentes maneras. Algunos bloquean la capacidad de las células tumorales para crecer y diseminarse. Otros localizan las células tumorales y ayudan a destruirlas o transportan sustancias que destruyen el tumor hacia ellas. El cetuximab y el ramucirumab también pueden detener el crecimiento del cáncer colorrectal al bloquear el flujo sanguíneo hacia el tumor. Aún no se sabe si la administración conjunta de cetuximab y clorhidrato de irinotecán es más eficaz con o sin ramucirumab en el tratamiento del cáncer colorrectal.

OBJETIVO: Este ensayo aleatorizado de fase II está estudiando los efectos secundarios y la eficacia de la administración de cetuximab y clorhidrato de irinotecán, con o sin ramucirumab, en el tratamiento de pacientes con cáncer colorrectal avanzado con enfermedad progresiva después del tratamiento con quimioterapia que contiene bevacizumab.

Evidencia de la diana molecular en cáncer colorrectal

Aún no hay evidencia documentada en nuestra base para la diana o el fármaco de este ensayo. Esta sección crece a medida que se procesan nuevas publicaciones.

Criterios de Elegibilidad

Criterios de inclusión:

  • Enfermedad medible
  • Adenocarcinoma de colon o recto confirmado histológicamente
  • Pacientes con K-ras tipo salvaje, según el tumor primario o metastásico
  • Deben haber recibido previamente terapia de primera línea que incluya quimioterapia con oxaliplatino y un fluoropirimidínico, además de bevacizumab para el cáncer colorrectal metastásico
  • Inscripción dentro de los 42 días posteriores a la confirmación de la progresión de la enfermedad
  • Estado funcional 0-1
  • Conteo de neutrófilos absoluto (ANC) ≥ 1.500/μL
  • Conteo de plaquetas ≥ 75.000/μL
  • Hemoglobina ≥ 9 g/dL
  • Creatinina sérica ≤ 1,5 veces el límite superior normal (ULN) O aclaramiento de creatinina ≥ 40 mL/min
  • Proteína en orina ≤ 1+ en la tira reactiva o en el análisis de orina de rutina (si ≥ 2+, una recolección de orina de 24 horas debe demostrar < 1.000 mg de proteína)
  • Bilirrubina total ≤ 2,0 mg/dL
  • AST y ALT ≤ 3,0 veces el ULN (5,0 veces el ULN para pacientes con metástasis hepáticas)
  • INR ≤ 1,6 (≤ 3,0 para pacientes que toman warfarina y no presentan sangrado activo [es decir, sin sangrado en los últimos 14 días])
  • Prueba de embarazo negativa
  • Los pacientes fértiles deben utilizar métodos anticonceptivos eficaces durante y hasta 3 meses después de la finalización de la terapia del estudio
  • Al menos 28 días y no más de 90 días desde la administración previa de bevacizumab
  • Se permite el uso concomitante de una dosis estable de anticoagulantes orales o heparina de bajo peso molecular

Criterios de exclusión:

  • Metástasis cerebrales o del sistema nervioso central (SNC)
  • Embarazo o lactancia
  • Terapia previa con fármacos distintos de oxaliplatino y un fluoropirimidínico, además de bevacizumab para el cáncer colorrectal
  • Episodios de sangrado clínicamente significativos (equivalentes al grado 3-4 de la NCI CTCAE) en los últimos 3 meses
  • Infección activa
  • Insuficiencia cardíaca congestiva sintomática
  • Angina inestable
  • Arritmia cardíaca sintomática o mal controlada
  • Trastorno trombótico o hemorrágico no controlado
  • Hipertensión no controlada o mal controlada a pesar del tratamiento médico estándar (por ejemplo, presión arterial sistólica consistentemente > 160 mm Hg y presión arterial diastólica > 90 mm Hg)
  • Eventos trombóticos arteriales agudos en los últimos 6 meses, incluido un accidente cerebrovascular, un ataque isquémico transitorio, un infarto de miocardio o una angina inestable
  • Otro cáncer que requiera tratamiento en los últimos 3 años, excepto el carcinoma in situ o el cáncer de piel no melanoma
  • Obstrucción intestinal aguda o subaguda
  • Antecedentes de enfermedad inflamatoria intestinal que requieran intervención farmacológica y/o quirúrgica en los últimos 12 meses
  • Alergia conocida a alguno de los componentes del tratamiento
  • Cirugía mayor en los últimos 28 días
  • Colocación de un dispositivo de acceso venoso subcutáneo en los últimos 7 días

Información del Ensayo

NCT01079780
Archived
Fase 2
136 participantes
Ene 2011
Feb 2021

Ubicaciones255

United States (255)
UAB Comprehensive Cancer Center
Birmingham, Alabama, 35294
Aurora Presbyterian Hospital
Aurora, Colorado, 80012
Boulder Community Hospital
Boulder, Colorado, 80301-9019
Penrose Cancer Center at Penrose Hospital
Colorado Springs, Colorado, 80933
CCOP - Colorado Cancer Research Program
Denver, Colorado, 80224-2522
Porter Adventist Hospital
Denver, Colorado, 80210
Presbyterian - St. Luke's Medical Center
Denver, Colorado, 80218
Rose Medical Center
Denver, Colorado, 80220
St. Anthony Central Hospital
Denver, Colorado, 80204
St. Joseph Hospital
Denver, Colorado, 80218
Swedish Medical Center
Englewood, Colorado, 80110
Front Range Cancer Specialists
Fort Collins, Colorado, 80528
Poudre Valley Hospital
Fort Collins, Colorado, 80524
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
Grand Junction, Colorado, 81502
North Colorado Medical Center
Greeley, Colorado, 80631
Littleton Adventist Hospital
Littleton, Colorado, 80122
Sky Ridge Medical Center
Lone Tree, Colorado, 80124
Hope Cancer Care Center at Longmont United Hospital
Longmont, Colorado, 80501
McKee Medical Center
Loveland, Colorado, 80539
Parker Adventist Hospital
Parker, Colorado, 80138
St. Mary - Corwin Regional Medical Center
Pueblo, Colorado, 81004
North Suburban Medical Center
Thornton, Colorado, 80229
Exempla Lutheran Medical Center
Wheat Ridge, Colorado, 80033
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
Hartford, Connecticut, 06105
Yale Cancer Center
New Haven, Connecticut, 06520-8028
Veterans Affairs Medical Center - Atlanta (Decatur)
Decatur, Georgia, 30033
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
Savannah, Georgia, 31405
Rush-Copley Cancer Care Center
Aurora, Illinois, 60504
St. Joseph Medical Center
Bloomington, Illinois, 61701
Graham Hospital
Canton, Illinois, 61520
Memorial Hospital
Carthage, Illinois, 62321
Hematology and Oncology Associates
Chicago, Illinois, 60611
John H. Stroger, Jr. Hospital of Cook County
Chicago, Illinois, 60612-3785
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, 60611-3013
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, 62526
Eureka Community Hospital
Eureka, Illinois, 61530
Galesburg Clinic, PC
Galesburg, Illinois, 61401
Mason District Hospital
Havana, Illinois, 62644
Kellogg Cancer Care Center
Highland Park, Illinois, 60035
Hinsdale Hematology Oncology Associates
Hinsdale, Illinois, 60521
Provena St. Mary's Regional Cancer Center - Kankakee
Kankakee, Illinois, 60901
North Shore Oncology and Hematology Associates, Limited - Libertyville
Libertyville, Illinois, 60048
McDonough District Hospital
Macomb, Illinois, 61455
Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
Moline, Illinois, 61265
Cancer Care and Hematology Specialists of Chicagoland - Niles
Niles, Illinois, 60714
BroMenn Regional Medical Center
Normal, Illinois, 61761
Community Cancer Center
Normal, Illinois, 61761
Advocate Christ Medical Center
Oak Lawn, Illinois, 60453-2699
Community Hospital of Ottawa
Ottawa, Illinois, 61350
Cancer Treatment Center at Pekin Hospital
Pekin, Illinois, 61554
CCOP - Illinois Oncology Research Association
Peoria, Illinois, 61615
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
Oncology Hematology Associates of Central Illinois, PC - Peoria
Peoria, Illinois, 61615
OSF St. Francis Medical Center
Peoria, Illinois, 61637
Proctor Hospital
Peoria, Illinois, 61614
Illinois Valley Community Hospital
Peru, Illinois, 61354
Perry Memorial Hospital
Princeton, Illinois, 61356
West Suburban Center for Cancer Care
River Forest, Illinois, 60305
Swedish-American Regional Cancer Center
Rockford, Illinois, 61104-2315
Hematology Oncology Associates - Skokie
Skokie, Illinois, 60076
Regional Cancer Center at Memorial Medical Center
Springfield, Illinois, 62781-0001
CCOP - Carle Cancer Center
Urbana, Illinois, 61801
Indiana University Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202-5289
William N. Wishard Memorial Hospital
Indianapolis, Indiana, 46202
Clarian Arnett Cancer Care
Lafayette, Indiana, 47904
Saint Anthony Memorial Health Centers
Michigan City, Indiana, 46360
McFarland Clinic, PC
Ames, Iowa, 50010
Cedar Rapids Oncology Associates
Cedar Rapids, Iowa, 52403
Mercy Regional Cancer Center at Mercy Medical Center
Cedar Rapids, Iowa, 52403
Medical Oncology and Hematology Associates - West Des Moines
Clive, Iowa, 50325
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, 50309
John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines, Iowa, 50316
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, 50309
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Des Moines, Iowa, 50309
Medical Oncology and Hematology Associates at Mercy Cancer Center
Des Moines, Iowa, 50314
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
Mercy Cancer Center at Mercy Medical Center - North Iowa
Mason City, Iowa, 50401
McCreery Cancer Center at Ottumwa Regional
Ottumwa, Iowa, 52501
Mercy Medical Center - Sioux City
Sioux City, Iowa, 51102
Siouxland Hematology-Oncology Associates, LLP
Sioux City, Iowa, 51101
St. Luke's Regional Medical Center
Sioux City, Iowa, 51104
Cancer Center of Kansas, PA - Chanute
Chanute, Kansas, 66720
Cancer Center of Kansas, PA - Dodge City
Dodge City, Kansas, 67801
Cancer Center of Kansas, PA - El Dorado
El Dorado, Kansas, 67042
Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas, 66701
Cancer Center of Kansas-Independence
Independence, Kansas, 67301
Cancer Center of Kansas, PA - Kingman
Kingman, Kansas, 67068
Lawrence Memorial Hospital
Lawrence, Kansas, 66044
Cancer Center of Kansas, PA - Liberal
Liberal, Kansas, 67901
Cancer Center of Kansas, PA - McPherson
McPherson, Kansas, 67460
Cancer Center of Kansas, PA - Newton
Newton, Kansas, 67114
Cancer Center of Kansas, PA - Parsons
Parsons, Kansas, 67357
Cancer Center of Kansas, PA - Pratt
Pratt, Kansas, 67124
Cancer Center of Kansas, PA - Salina
Salina, Kansas, 67401
Cancer Center of Kansas, PA - Wellington
Wellington, Kansas, 67152
Associates in Womens Health, PA - North Review
Wichita, Kansas, 67208
Cancer Center of Kansas, PA - Medical Arts Tower
Wichita, Kansas, 67208
Cancer Center of Kansas, PA - Wichita
Wichita, Kansas, 67214
CCOP - Wichita
Wichita, Kansas, 67214
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, 67214
Cancer Center of Kansas, PA - Winfield
Winfield, Kansas, 67156
Mary Bird Perkins Cancer Center - Baton Rouge
Baton Rouge, Louisiana, 70809
Ochsner Health Center - Bluebonnet
Baton Rouge, Louisiana, 70809
Ochsner Health Center - Covington
Covington, Louisiana, 70433
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112
Medical Center of Louisiana - New Orleans
New Orleans, Louisiana, 70112
Ochsner Cancer Institute at Ochsner Clinic Foundation
New Orleans, Louisiana, 70121
Greater Baltimore Medical Center Cancer Center
Baltimore, Maryland, 21204
Baystate Regional Cancer Program at D'Amour Center for Cancer Care
Springfield, Massachusetts, 01199
Hickman Cancer Center at Bixby Medical Center
Adrian, Michigan, 49221
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, 48106
Saint Joseph Mercy Cancer Center
Ann Arbor, Michigan, 48106-0995
Oakwood Cancer Center at Oakwood Hospital and Medical Center
Dearborn, Michigan, 48123-2500
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
Hurley Medical Center
Flint, Michigan, 48503
Van Elslander Cancer Center at St. John Hospital and Medical Center
Grosse Pointe Woods, Michigan, 48236
Foote Memorial Hospital
Jackson, Michigan, 49201
Borgess Medical Center
Kalamazoo, Michigan, 49001
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
West Michigan Cancer Center
Kalamazoo, Michigan, 49007-3731
Sparrow Regional Cancer Center
Lansing, Michigan, 48912-1811
St. Mary Mercy Hospital
Livonia, Michigan, 48154
Community Cancer Center of Monroe
Monroe, Michigan, 48162
Mercy Memorial Hospital - Monroe
Monroe, Michigan, 48162
St. Joseph Mercy Oakland
Pontiac, Michigan, 48341-2985
Mercy Regional Cancer Center at Mercy Hospital
Port Huron, Michigan, 48060
Seton Cancer Institute at Saint Mary's - Saginaw
Saginaw, Michigan, 48601
St. John Macomb Hospital
Warren, Michigan, 48093
MeritCare Bemidji
Bemidji, Minnesota, 56601
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids, Minnesota, 55433
CCOP - Duluth
Duluth, Minnesota, 55805
Duluth Clinic Cancer Center - Duluth
Duluth, Minnesota, 55805-1983
Miller - Dwan Medical Center
Duluth, Minnesota, 55805
Fairview Southdale Hospital
Edina, Minnesota, 55435
Mercy and Unity Cancer Center at Unity Hospital
Fridley, Minnesota, 55432
Hutchinson Area Health Care
Hutchinson, Minnesota, 55350
HealthEast Cancer Care at St. John's Hospital
Maplewood, Minnesota, 55109
Minnesota Oncology - Maplewood
Maplewood, Minnesota, 55109
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, 55415
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
Minneapolis, Minnesota, 55407
New Ulm Medical Center
New Ulm, Minnesota, 56073
Humphrey Cancer Center at North Memorial Outpatient Center
Robbinsdale, Minnesota, 55422-2900
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, 55416
Park Nicollet Cancer Center
Saint Louis Park, Minnesota, 55416
Regions Hospital Cancer Care Center
Saint Paul, Minnesota, 55101
United Hospital
Saint Paul, Minnesota, 55102
St. Francis Cancer Center at St. Francis Medical Center
Shakopee, Minnesota, 55379
Lakeview Hospital
Stillwater, Minnesota, 55082
Ridgeview Medical Center
Waconia, Minnesota, 55387
Willmar Cancer Center at Rice Memorial Hospital
Willmar, Minnesota, 56201
Minnesota Oncology - Woodbury
Woodbury, Minnesota, 55125
Cancer Resource Center - Lincoln
Lincoln, Nebraska, 68510
Alegant Health Cancer Center at Bergan Mercy Medical Center
Omaha, Nebraska, 68124
CCOP - Missouri Valley Cancer Consortium
Omaha, Nebraska, 68106
Creighton University Medical Center
Omaha, Nebraska, 68131-2197
Immanuel Medical Center
Omaha, Nebraska, 68122
Lakeside Hospital
Omaha, Nebraska, 68130
Veterans Affairs Medical Center - East Orange
East Orange, New Jersey, 07018-1095
Hunterdon Regional Cancer Center at Hunterdon Medical Center
Flemington, New Jersey, 08822
CentraState Medical Center
Freehold, New Jersey, 07728
Hematology Oncology Associates, PC
Albuquerque, New Mexico, 87106
Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital
Albuquerque, New Mexico, 87110
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87131-5636
New Mexico Cancer Care Associates
Santa Fe, New Mexico, 87505
NYU Cancer Institute at New York University Medical Center
New York, New York, 10016
CCOP - MeritCare Hospital
Fargo, North Dakota, 58122
Roger Maris Cancer Center at MeritCare Hospital
Fargo, North Dakota, 58122
Summa Center for Cancer Care at Akron City Hospital
Akron, Ohio, 44309-2090
Wood County Oncology Center
Bowling Green, Ohio, 43402
Adena Regional Medical Center
Chillicothe, Ohio, 45601
Case Comprehensive Cancer Center
Cleveland, Ohio, 44106-5065
MetroHealth Cancer Care Center at MetroHealth Medical Center
Cleveland, Ohio, 44109
CCOP - Columbus
Columbus, Ohio, 43215
Doctors Hospital at Ohio Health
Columbus, Ohio, 43228
Grant Medical Center Cancer Care
Columbus, Ohio, 43215
Mount Carmel Health - West Hospital
Columbus, Ohio, 43222
Riverside Methodist Hospital Cancer Care
Columbus, Ohio, 43214-3998
Grady Memorial Hospital
Delaware, Ohio, 43015
Community Cancer Center
Elyria, Ohio, 44035
Hematology Oncology Center
Elyria, Ohio, 44035
Fairfield Medical Center
Lancaster, Ohio, 43130
Lima Memorial Hospital
Lima, Ohio, 45804
St. Rita's Medical Center
Lima, Ohio, 45801
Strecker Cancer Center at Marietta Memorial Hospital
Marietta, Ohio, 45750
Northwest Ohio Oncology Center
Maumee, Ohio, 43537-1839
Knox Community Hospital
Mount Vernon, Ohio, 43050
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark, Ohio, 43055
St. Charles Mercy Hospital
Oregon, Ohio, 43616
Toledo Clinic - Oregon
Oregon, Ohio, 43616
North Coast Cancer Care, Incorporated
Sandusky, Ohio, 44870
Community Hospital of Springfield and Clark County
Springfield, Ohio, 45505
Flower Hospital Cancer Center
Sylvania, Ohio, 43560
Mercy Hospital of Tiffin
Tiffin, Ohio, 44883
CCOP - Toledo Community Hospital
Toledo, Ohio, 43617
Medical University of Ohio Cancer Center
Toledo, Ohio, 43614
St. Anne Mercy Hospital
Toledo, Ohio, 43623
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608
Toledo Clinic, Incorporated - Main Clinic
Toledo, Ohio, 43623
Toledo Hospital
Toledo, Ohio, 43606
Fulton County Health Center
Wauseon, Ohio, 43567
Mount Carmel St. Ann's Cancer Center
Westerville, Ohio, 43081
Genesis - Good Samaritan Hospital
Zanesville, Ohio, 43701
Natalie Warren Bryant Cancer Center at St. Francis Hospital
Tulsa, Oklahoma, 74136
St. Luke's Cancer Network at St. Luke's Hospital
Bethlehem, Pennsylvania, 18015
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, 19010
Geisinger Cancer Institute at Geisinger Health
Danville, Pennsylvania, 17822-0001
Doylestown Hospital Cancer Center
Doylestown, Pennsylvania, 18901
PinnacleHealth Regional Cancer Center at Polyclinic Hospital
Harrisburg, Pennsylvania, 17110-2098
Geisinger Hazleton Cancer Center
Hazleton, Pennsylvania, 18201
Cancer Center of Paoli Memorial Hospital
Paoli, Pennsylvania, 19301-1792
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104-4283
Fox Chase Cancer Center - Philadelphia
Philadelphia, Pennsylvania, 19111-2497
Joan Karnell Cancer Center at Pennsylvania Hospital
Philadelphia, Pennsylvania, 19107
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, 19107-5541
Pottstown Memorial Regional Cancer Center
Pottstown, Pennsylvania, 19464
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
Reading, Pennsylvania, 19612-6052
Hematology and Oncology Associates of Northeastern Pennsylvania
Scranton, Pennsylvania, 18508
Grand View Hospital
Sellersville, Pennsylvania, 18960
Geisinger Medical Group - Scenery Park
State College, Pennsylvania, 16801
Chester County Hospital
West Chester, Pennsylvania, 19380
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, 18711
CCOP - Main Line Health
Wynnewood, Pennsylvania, 19096
Lankenau Cancer Center at Lankenau Hospital
Wynnewood, Pennsylvania, 19096
Sanford Cancer Center at Sanford USD Medical Center
Sioux Falls, South Dakota, 57117-5039
Parkland Memorial Hospital
Dallas, Texas, 75235
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas, Texas, 75390
CCOP - Scott and White Hospital
Temple, Texas, 76508
Fredericksburg Oncology, Incorporated
Fredericksburg, Virginia, 22401
West Virginia University Health Sciences Center - Charleston
Charleston, West Virginia, 25304
Langlade Memorial Hospital
Antigo, Wisconsin, 54409
Marshfield Clinic Cancer Care at Regional Cancer Center
Eau Claire, Wisconsin, 54701
St. Vincent Hospital Regional Cancer Center
Green Bay, Wisconsin, 54307-3508
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311
UW Cancer Center Johnson Creek
Johnson Creek, Wisconsin, 53038
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Madison, Wisconsin, 53792-6164
Holy Family Memorial Medical Center Cancer Care Center
Manitowoc, Wisconsin, 54221-1450
Bay Area Cancer Care Center at Bay Area Medical Center
Marinette, Wisconsin, 54143
Vince Lombardi Cancer Clinic - Marinette
Marinette, Wisconsin, 54143
Marshfield Clinic - Marshfield Center
Marshfield, Wisconsin, 54449
Marshfield Clinic - Lakeland Center
Minocqua, Wisconsin, 54548
Regional Cancer Center at Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
Ministry Medical Group at Saint Mary's Hospital
Rhinelander, Wisconsin, 54501
Marshfield Clinic - Indianhead Center
Rice Lake, Wisconsin, 54868
St. Nicholas Hospital
Sheboygan, Wisconsin, 53081
Vince Lombardi Cancer Clinic - Sheboygan
Sheboygan, Wisconsin, 53081
Marshfield Clinic at Saint Michael's Hospital
Stevens Point, Wisconsin, 54481
Aurora Medical Center
Summit, Wisconsin, 53066
Vince Lombardi Cancer Clinic - Two Rivers
Two Rivers, Wisconsin, 54241
Waukesha Memorial Hospital Regional Cancer Center
Waukesha, Wisconsin, 53188
University of Wisconcin Cancer Center at Aspirus Wausau Hospital
Wausau, Wisconsin, 54401
Diagnostic and Treatment Center
Weston, Wisconsin, 54476
Marshfield Clinic - Weston Center
Weston, Wisconsin, 54476
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin, 54494
Riverview UW Cancer Center at Riverview Hospital
Wisconsin Rapids, Wisconsin, 54494

Fuente Oficial

Ver en ClinicalTrials.gov