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NCT02921256

Veliparib, pembrolizumab y quimioterapia combinada en el tratamiento de pacientes con cáncer de recto localmente avanzado.

Archived Fase 2

Descripción

Este ensayo aleatorizado de fase II estudia la eficacia de veliparib o pembrolizumab en combinación con quimioterapia y radioterapia en el tratamiento de pacientes con cáncer de recto que se ha extendido desde su lugar de origen a los tejidos o ganglios linfáticos cercanos (cáncer localmente avanzado). Veliparib puede detener el crecimiento de las células tumorales al bloquear algunas de las enzimas necesarias para el crecimiento celular. La inmunoterapia con anticuerpos monoclonales, como pembrolizumab, puede ayudar al sistema inmunitario del cuerpo a atacar el cáncer y puede interferir con la capacidad de las células tumorales para crecer y diseminarse. Los fármacos utilizados en la quimioterapia, como el régimen modificado (m)FOLFOX6, actúan de diferentes maneras para detener el crecimiento de las células tumorales, ya sea matando las células, impidiendo que se dividan o impidiendo que se diseminen. La radioterapia utiliza rayos X de alta energía para matar las células tumorales y reducir el tamaño de los tumores. La administración de veliparib o pembrolizumab en combinación con quimioterapia y radioterapia puede matar más células tumorales, reducir el tamaño del tumor y disminuir la cantidad de tejido normal que debe extirparse.

Evidencia de la diana molecular en cáncer colorrectal

Aún no hay evidencia documentada en nuestra base para la diana o el fármaco de este ensayo. Esta sección crece a medida que se procesan nuevas publicaciones.

Criterios de Elegibilidad

Criterios de inclusión:

  • El paciente debe haber firmado y fechado un formulario de consentimiento aprobado por una Junta de Revisión Institucional (IRB) que cumpla con las directrices federales e institucionales.
  • Estado funcional según la Escala de ECOG de 0, 1 o 2.
  • Diagnóstico de adenocarcinoma del recto con la mayor parte del tumor intacta; Nota: antes de la aleatorización, el investigador debe especificar y documentar cada uno de los siguientes aspectos:
  • Distancia del borde inferior del tumor al ano; y
  • Intención de resección quirúrgica con preservación o sin preservación del esfínter, según el criterio del cirujano principal; y
  • La mayor parte del tumor no tratado debe estar a menos de 12 cm del ano o por debajo de la reflexión peritoneal, según lo determine el cirujano tratante.
  • El tumor debe determinarse clínicamente como cáncer de recto localmente avanzado en estadio II o III, y también debe cumplir con alguno de los siguientes criterios:
  • Localización distal (según se define mediante la medición en resonancia magnética \[RM], ecografía transrectal \[ERUS]/tomografía computarizada \[TC] pélvica \[con contraste IV] o palpación en el examen rectal digital \[ERD]): cT3-4 <= 5 cm del ano, cualquier N.
  • Tumor voluminoso: cualquier cT4 o evidencia de que el tumor es adyacente (definido como dentro de 3 mm) a la fascia mesorrectal en la RM o ERUS/TC pélvica (con contraste IV).
  • Alto riesgo de enfermedad metastásica con 4 o más ganglios linfáticos regionales (cN2); el estado clínico de los ganglios ("cN") para la elegibilidad incluye el número total de ganglios (N2 = 4 o más) en las estaciones mesorrectal y rectal superior que midan >= 1,0 cm en cualquier eje en imágenes transversales o endoscópicas; Nota: los ganglios deben medir 1,0 cm o más para considerarse positivos para este requisito de elegibilidad.
  • No es candidato para la resección quirúrgica con preservación del esfínter antes de la terapia neoadyuvante (según lo planeado por el cirujano principal).
  • Nota: el estadio clínico del tumor primario y los ganglios puede determinarse localmente mediante ecografía endoscópica rectal o RM pélvica (se prefiere encarecidamente la RM pélvica); la TC con contraste IV es aceptable siempre que haya evidencia de enfermedad T4 y/o N2.
  • Los pacientes deben tener la capacidad de tragar y retener medicamentos orales.
  • El recuento absoluto de neutrófilos (RAN) debe ser >= 1200/mm^3 (dentro de los 28 días antes de la aleatorización).
  • El recuento de plaquetas debe ser >= 100.000/mm^3 (dentro de los 28 días antes de la aleatorización).
  • La hemoglobina debe ser >= 10 g/dL (dentro de los 28 días antes de la aleatorización).
  • La bilirrubina total debe ser <= LSN (límite superior de la normalidad) para el laboratorio, a menos que el paciente tenga un aumento de la bilirrubina > LSN hasta 1,5 x LSN debido a la enfermedad de Gilbert o un síndrome similar que implique una conjugación lenta de la bilirrubina (dentro de los 28 días antes de la aleatorización).
  • La fosfatasa alcalina debe ser <= 3 x LSN para el laboratorio (dentro de los 28 días antes de la aleatorización).
  • La aspartato aminotransferasa (AST) debe ser <= 3 x LSN para el laboratorio (dentro de los 28 días antes de la aleatorización);
  • Nota: si se realiza alanina aminotransferasa (ALT) en lugar de AST (según la práctica estándar de la institución), el valor de ALT debe ser <= 3 x LSN; si se realizaron ambas, la AST también debe ser <= 3 x LSN; si la AST y/o la ALT son >= LSN pero <= 3 x LSN, se deben realizar pruebas serológicas para hepatitis B y C, y los resultados para la infección viral deben ser negativos.
  • Creatinina sérica <= LSN para el laboratorio y aclaramiento de creatinina medido o calculado > 60 mL/min (dentro de los 28 días antes de la aleatorización).
  • Los niveles de potasio, magnesio y calcio séricos dentro de los 28 días antes de la aleatorización deben estar dentro de los límites normales (LMN) para el laboratorio.
  • La relación normalizada internacional (RNI) del tiempo de protrombina dentro de los 28 días antes de la aleatorización debe ser <= LSN para el laboratorio; los pacientes que reciben tratamiento con un agente como la warfarina pueden participar si están en una dosis estable y no existe ninguna anomalía subyacente en los parámetros de coagulación según la historia clínica.
  • Los pacientes con síndrome de inmunodeficiencia adquirida (enfermedades relacionadas con el SIDA) o enfermedad conocida por el virus de la inmunodeficiencia humana (VIH) deben:
  • Tener un recuento de células de diferenciación (CD) 4 >= 200 células/uL dentro de los 30 días antes de comenzar la terapia del estudio.
  • No estar tomando ninguna terapia antirretroviral (profilaxis/tratamiento) durante más de 60 días antes de comenzar la terapia del estudio, y
  • No tener evidencia de infecciones oportunistas.
  • La prueba de embarazo (orina o suero beta-gonadotropina coriónica humana \[HCG]) realizada dentro de las 72 horas antes de la aleatorización debe ser negativa (solo para mujeres en edad fértil); si los resultados de la prueba de embarazo en orina son positivos o no se pueden confirmar como negativos, se requerirá una prueba de embarazo en suero.

Criterios de exclusión:

  • Histología de cáncer de recto distinta de adenocarcinoma (es decir, sarcoma, linfoma, carcinoma de células escamosas, melanoma mucoso, etc.).
  • Evidencia clínica o radiológica definitiva de enfermedad metastásica; los estudios de imagen requeridos deben haberse realizado dentro de los 28 días antes de la aleatorización; Nota: la estadificación clínica a distancia para excluir a los pacientes con enfermedad metastásica manifiesta se determina por:
  • Tórax: TC (preferida); radiografía de tórax pósteroanterior (PA) y lateral (aceptable); o tomografía por emisión de positrones (PET) (aceptable).
  • Abdomen: TC con contraste IV (preferida); o RM (aceptable).
  • Pelvis: RM (preferida) o TC con contraste IV (aceptable).
  • (Se recomienda que se utilicen los mismos estudios de imagen que se realizan antes de la aleatorización en los puntos de seguimiento; Nota: las TC del abdomen y la pelvis deben realizarse con contraste IV).
  • Antecedentes de malignidad rectal invasiva previa, independientemente del intervalo libre de enfermedad.
  • Enfermedad cardíaca que impediría el uso de cualquiera de los fármacos incluidos en el régimen de tratamiento GI002; esto incluye, entre otros:
  • Enfermedad cardíaca clínicamente inestable, incluida la fibrilación auricular inestable, la bradicardia sintomática, la insuficiencia cardíaca congestiva inestable, la isquemia miocárdica activa o un marcapasos temporal en su lugar.
  • Taquicardia ventricular o taquicardia supraventricular que requiera tratamiento con fármacos antiarrítmicos de clase Ia (por ejemplo, quinidina, procainamida, disopiramida) o fármacos antiarrítmicos de clase III (por ejemplo, sotalol, amiodarona, dofetilida); se permite el uso de otros fármacos antiarrítmicos.
  • Bloqueo auriculoventricular (AV) de segundo o tercer grado a menos que se trate con un marcapasos permanente.
  • Bloqueo de rama izquierda completo (BRI).
  • Antecedentes de síndrome de QT largo.
  • QT corregido (QTc) >= 450 ms.
  • Neuropatía sensorial o motora >= grado 2.
  • Antecedentes de, o cualquier evidencia de, neumonitis no infecciosa activa.
  • Enfermedad inflamatoria intestinal activa (es decir, pacientes que requieren intervenciones médicas actuales o que tienen síntomas) o que tienen antecedentes de cirugía abdominal u otra afección médica que, en opinión del médico tratante, pueda interferir con la motilidad o la absorción gastrointestinal.
  • Enfermedad autoinmune activa que haya requerido tratamiento sistémico en los últimos 2 años (es decir, con el uso de agentes modificadores, corticosteroides o fármacos inmunosupresores); la terapia de reemplazo (por ejemplo, tiroxina, insulina o terapia de reemplazo fisiológica de corticosteroides para insuficiencia adrenal o pituitaria, etc.) no se considera una forma de tratamiento sistémico.
  • Antecedentes de TB activa (Bacillus tuberculosis).
  • Infección activa o crónica que requiera terapia sistémica.
  • Diagnóstico de inmunodeficiencia o recepción de terapia con esteroides sistémicos o cualquier otra forma de terapia inmunosupresora dentro de los 7 días antes de la primera dosis de la terapia del estudio; el uso de dosis fisiológicas de corticosteroides puede ser aprobado después de consultar con el investigador principal del estudio (IP).
  • Trastorno convulsivo activo no controlado con medicación.
  • Cualquier terapia antineoplásica para este cáncer antes de la aleatorización.
  • Cáncer de colon sincrónico.
  • Otro cáncer invasivo dentro de los 5 años antes de la aleatorización; las excepciones son los pólipos colorrectales, el cáncer de piel no melanoma o el carcinoma in situ del cuello uterino.
  • Terapia antineoplásica (por ejemplo, quimioterapia o terapia dirigida) para otro cáncer invasivo dentro de los 5 años antes de la aleatorización; (a los efectos de este estudio, la terapia hormonal no se considera quimioterapia).
  • Tratamiento previo con un compuesto de investigación que se está probando en este estudio (por ejemplo, inhibidor de la poli (ADP-ribosa) polimerasa \[PARP], anti-PD-1, anti-PD-L1 o anti-PD-L2).
  • Recepción de vacuna viva dentro de los 28 días antes de la aleatorización; se permiten las vacunas contra la gripe estacionales que no contengan virus vivos.
  • Cirugía mayor dentro de las 4 semanas antes de la aleatorización.
  • Radiación pélvica terapéutica conocida.
  • Deficiencia conocida de DPD (dihidropirimidina deshidrogenasa) homocigota.
  • Cualquiera de los siguientes, ya que este estudio implica agentes que tienen efectos genotóxicos o mutagénicos y teratogénicos conocidos o potenciales:
  • Mujeres embarazadas.
  • Mujeres lactantes que no estén dispuestas a interrumpir la lactancia.
  • Hombres o mujeres en edad fértil que no estén dispuestos a utilizar métodos anticonceptivos adecuados (por ejemplo, métodos anticonceptivos hormonales o de barrera; abstinencia) durante la duración del tratamiento del estudio y durante 4 meses después de la última dosis de la terapia del estudio.
  • Otras enfermedades o afecciones concurrentes que, a juicio del médico que obtiene el consentimiento informado, harían que el paciente no fuera adecuado para participar en este estudio o interfirieran significativamente con la evaluación adecuada de la seguridad y la toxicidad de los regímenes prescritos o impidieran el seguimiento requerido.

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Información del Ensayo

NCT02921256
Archived
Fase 2
363 participantes
Ene 2017
Abr 2020

Ubicaciones650

Puerto Rico (5)
Cancer Center-Metro Medical Center Bayamon
Bayamón, 00959-5060
Doctors Cancer Center
Manatí, 00674
Centro Comprensivo de Cancer de UPR
San Juan, 00927
San Juan City Hospital
San Juan, 00936
San Juan Community Oncology Group
San Juan, 00917
United States (645)
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
Southern Cancer Center PC-Mobile
Mobile, Alabama, 36607
Southern Cancer Center PC-Providence
Mobile, Alabama, 36608
Southern Cancer Center PC-Springhill
Mobile, Alabama, 36608
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, 36688
Fairbanks Memorial Hospital
Fairbanks, Alaska, 99701
Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234
Mayo Clinic in Arizona
Scottsdale, Arizona, 85259
Banner University Medical Center - Tucson
Tucson, Arizona, 85719
University of Arizona Cancer Center-North Campus
Tucson, Arizona, 85719
University of Arizona Cancer Center-Orange Grove Campus
Tucson, Arizona, 85704
Mercy Hospital Fort Smith
Fort Smith, Arkansas, 72903
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs, Arkansas, 71913
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, 72401
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
Kaiser Permanente-Anaheim
Anaheim, California, 92806
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, 94531
PCR Oncology
Arroyo Grande, California, 93420
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, 95603
AIS Cancer Center at San Joaquin Community Hospital
Bakersfield, California, 93301
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, 94704
Mills-Peninsula Medical Center
Burlingame, California, 94010
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, 95682
Eden Hospital Medical Center
Castro Valley, California, 94546
Enloe Medical Center
Chico, California, 95926
City of Hope Corona
Corona, California, 92879
City of Hope Comprehensive Cancer Center
Duarte, California, 91010
Kaiser Permanente Dublin
Dublin, California, 94568
Kaiser Permanente-Fremont
Fremont, California, 94538
Fresno Cancer Center
Fresno, California, 93720
Kaiser Permanente-Fresno
Fresno, California, 93720
UC San Diego Moores Cancer Center
La Jolla, California, 92093
City of Hope Antelope Valley
Lancaster, California, 93534
Cedars Sinai Medical Center
Los Angeles, California, 90048
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027
Los Angeles County-USC Medical Center
Los Angeles, California, 90033
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033
Fremont - Rideout Cancer Center
Marysville, California, 95901
Kaiser Permanente-Modesto
Modesto, California, 95356
Memorial Medical Center
Modesto, California, 95355
Palo Alto Medical Foundation-Camino Division
Mountain View, California, 94040
Sutter Cancer Research Consortium
Novato, California, 94945
Kaiser Permanente Oakland-Broadway
Oakland, California, 94611
Kaiser Permanente-Oakland
Oakland, California, 94611
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868
Palo Alto Medical Foundation Health Care
Palo Alto, California, 94301
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, 95670
Kaiser Permanente-Redwood City
Redwood City, California, 94063
Kaiser Permanente-Richmond
Richmond, California, 94801
Kaiser Permanente-Riverside
Riverside, California, 92505
Rohnert Park Cancer Center
Rohnert Park, California, 94928
Kaiser Permanente-Roseville
Roseville, California, 95661
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, 95661
Sutter Roseville Medical Center
Roseville, California, 95661
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, 95678
Kaiser Permanente - Sacramento
Sacramento, California, 95825
Kaiser Permanente Downtown Commons
Sacramento, California, 95814
Kaiser Permanente-South Sacramento
Sacramento, California, 95823
South Sacramento Cancer Center
Sacramento, California, 95823
Sutter Medical Center Sacramento
Sacramento, California, 95816
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817
Kaiser Permanente-San Diego Zion
San Diego, California, 92120
California Pacific Medical Center-Pacific Campus
San Francisco, California, 94115
Kaiser Permanente-San Francisco
San Francisco, California, 94115
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, 95119
Kaiser Permanente San Leandro
San Leandro, California, 94577
Kaiser Permanente-San Marcos
San Marcos, California, 92078
Kaiser Permanente-San Rafael
San Rafael, California, 94903
Kaiser San Rafael-Gallinas
San Rafael, California, 94903
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051
Kaiser Permanente-Santa Rosa
Santa Rosa, California, 95403
City of Hope South Pasadena
South Pasadena, California, 91030
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, 94080
Kaiser Permanente-South San Francisco
South San Francisco, California, 94080
Kaiser Permanente-Stockton
Stockton, California, 95210
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California, 94086
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California, 96161
City of Hope Upland
Upland, California, 91786
Kaiser Permanente Medical Center-Vacaville
Vacaville, California, 95688
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Vacaville, California, 95687
Kaiser Permanente-Vallejo
Vallejo, California, 94589
Sutter Solano Medical Center/Cancer Center
Vallejo, California, 94589
Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596
Presbyterian Intercommunity Hospital
Whittier, California, 90602
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado, 80012
UCHealth University of Colorado Hospital
Aurora, Colorado, 80045
Boulder Community Hospital
Boulder, Colorado, 80301
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, 80304
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, 80907
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, 80909
Porter Adventist Hospital
Denver, Colorado, 80210
Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado, 80218
SCL Health Saint Joseph Hospital
Denver, Colorado, 80218
Swedish Medical Center
Englewood, Colorado, 80113
Poudre Valley Hospital
Fort Collins, Colorado, 80524
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado, 81501
North Colorado Medical Center
Greeley, Colorado, 80631
Saint Anthony Hospital
Lakewood, Colorado, 80228
Littleton Adventist Hospital
Littleton, Colorado, 80122
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado, 80120
Longmont United Hospital
Longmont, Colorado, 80501
McKee Medical Center
Loveland, Colorado, 80539
Saint Mary Corwin Medical Center
Pueblo, Colorado, 81004
Rocky Mountain Cancer Centers-Thornton
Thornton, Colorado, 80260
SCL Health Lutheran Medical Center
Wheat Ridge, Colorado, 80033
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437
Hartford Hospital
Hartford, Connecticut, 06102
Midstate Medical Center
Meriden, Connecticut, 06451
The Hospital of Central Connecticut
New Britain, Connecticut, 06050
Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510
Yale University
New Haven, Connecticut, 06520
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut, 06473
William Backus Hospital
Norwich, Connecticut, 06360
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385
Beebe Medical Center
Lewes, Delaware, 19958
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
Delaware Clinical and Laboratory Physicians PA
Newark, Delaware, 19713
Helen F Graham Cancer Center
Newark, Delaware, 19713
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
Beebe Health Campus
Rehoboth Beach, Delaware, 19971
TidalHealth Nanticoke / Allen Cancer Center
Seaford, Delaware, 19973
University of Florida Health Science Center - Gainesville
Gainesville, Florida, 32610
Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980
Orlando Health Cancer Institute
Orlando, Florida, 32806
Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342
Emory University Hospital Midtown
Atlanta, Georgia, 30308
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322
Northeast Georgia Medical Center-Gainesville
Gainesville, Georgia, 30501
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, 31405
Memorial Health University Medical Center
Savannah, Georgia, 31404
Pali Momi Medical Center
‘Aiea, Hawaii, 96701
Queen's Cancer Center - Pearlridge
‘Aiea, Hawaii, 96701
The Cancer Center of Hawaii-Pali Momi
‘Aiea, Hawaii, 96701
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, 96813
Hawaii Cancer Care Inc-Liliha
Honolulu, Hawaii, 96817
Island Urology
Honolulu, Hawaii, 96813
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, 96819
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826
Kuakini Medical Center
Honolulu, Hawaii, 96817
Queen's Cancer Center - Kuakini
Honolulu, Hawaii, 96817
Queen's Medical Center
Honolulu, Hawaii, 96813
Straub Clinic and Hospital
Honolulu, Hawaii, 96813
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii, 96817
University of Hawaii Cancer Center
Honolulu, Hawaii, 96813
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii, 96766
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
Idaho Urologic Institute-Meridian
Meridian, Idaho, 83642
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
Northwest Community Hospital
Arlington Heights, Illinois, 60005
Rush - Copley Medical Center
Aurora, Illinois, 60504
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
Memorial Hospital of Carbondale
Carbondale, Illinois, 62902
SIH Cancer Institute
Carterville, Illinois, 62918
Centralia Oncology Clinic
Centralia, Illinois, 62801
Advocate Illinois Masonic Medical Center
Chicago, Illinois, 60657
Northwestern University
Chicago, Illinois, 60611
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
Carle at The Riverfront
Danville, Illinois, 61832
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
Decatur Memorial Hospital
Decatur, Illinois, 62526
Carle Physician Group-Effingham
Effingham, Illinois, 62401
Crossroads Cancer Center
Effingham, Illinois, 62401
Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134
Ingalls Memorial Hospital
Harvey, Illinois, 60426
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, 60045
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
Loyola University Medical Center
Maywood, Illinois, 60153
Good Samaritan Regional Health Center
Mount Vernon, Illinois, 62864
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, 60451
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin, Illinois, 61554
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
OSF Saint Francis Medical Center
Peoria, Illinois, 61637
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, Illinois, 61615
Illinois CancerCare-Peru
Peru, Illinois, 61354
Valley Radiation Oncology
Peru, Illinois, 61354
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
SwedishAmerican Regional Cancer Center/ACT
Rockford, Illinois, 61114
Genesis Cancer Center - Silvis
Silvis, Illinois, 61282
Central Illinois Hematology Oncology Center
Springfield, Illinois, 62702
Memorial Medical Center
Springfield, Illinois, 62781
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
Springfield Clinic
Springfield, Illinois, 62702
Southwest Illinois Health Services LLP
Swansea, Illinois, 62226
Carle Cancer Center
Urbana, Illinois, 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555
Deaconess Clinic Downtown
Evansville, Indiana, 47713
Parkview Hospital Randallia
Fort Wayne, Indiana, 46805
Parkview Regional Medical Center
Fort Wayne, Indiana, 46845
Goshen Center for Cancer Care
Goshen, Indiana, 46526
Franciscan Health Indianapolis
Indianapolis, Indiana, 46237
Woodland Cancer Care Center
Michigan City, Indiana, 46360
Memorial Regional Cancer Center Day Road
Mishawaka, Indiana, 46545
Franciscan Health Mooresville
Mooresville, Indiana, 46158
Chancellor Center for Oncology
Newburgh, Indiana, 47630
Reid Health
Richmond, Indiana, 47374
Memorial Hospital of South Bend
South Bend, Indiana, 46601
Mary Greeley Medical Center
Ames, Iowa, 50010
McFarland Clinic - Ames
Ames, Iowa, 50010
Mercy Hospital
Cedar Rapids, Iowa, 52403
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa, 50325
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
Genesis Cancer Care Institute
Davenport, Iowa, 52804
Genesis Medical Center - East Campus
Davenport, Iowa, 52803
Iowa Cancer Specialists
Davenport, Iowa, 52807
Broadlawns Medical Center
Des Moines, Iowa, 50314
Iowa Lutheran Hospital
Des Moines, Iowa, 50316
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, 50309
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
Mission Cancer and Blood - Laurel
Des Moines, Iowa, 50314
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242
Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266
Methodist West Hospital
West Des Moines, Iowa, 50266-7700
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, 67801
Cancer Center of Kansas - El Dorado
El Dorado, Kansas, 67042
Central Care Cancer Center - Garden City
Garden City, Kansas, 67846
Central Care Cancer Center - Great Bend
Great Bend, Kansas, 67530
University of Kansas Cancer Center
Kansas City, Kansas, 66160
Lawrence Memorial Hospital
Lawrence, Kansas, 66044
Olathe Health Cancer Center
Olathe, Kansas, 66061
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, 66210
Ascension Via Christi - Pittsburg
Pittsburg, Kansas, 66762
Cancer Center of Kansas - Salina
Salina, Kansas, 67401
Salina Regional Health Center
Salina, Kansas, 67401
Cotton O'Neil Cancer Center / Stormont Vail Health
Topeka, Kansas, 66606
University of Kansas Health System Saint Francis Campus
Topeka, Kansas, 66606
Cancer Center of Kansas - Wellington
Wellington, Kansas, 67152
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205
Ascension Via Christi Hospitals Wichita
Wichita, Kansas, 67214
Associates In Womens Health
Wichita, Kansas, 67208
Cancer Center of Kansas - Wichita
Wichita, Kansas, 67214
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas, 67208
Wesley Medical Center
Wichita, Kansas, 67214
Cancer Center of Kansas - Winfield
Winfield, Kansas, 67156
Saint Joseph Hospital East
Lexington, Kentucky, 40509
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, 40504
Jewish Hospital
Louisville, Kentucky, 40202
UofL Health Medical Center Northeast
Louisville, Kentucky, 40245
Louisiana Hematology Oncology Associates LLC
Baton Rouge, Louisiana, 70809
LSU Health Baton Rouge-North Clinic
Baton Rouge, Louisiana, 70805
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, 70809
Our Lady of the Lake Physicians Group - Medical Oncology
Baton Rouge, Louisiana, 70809
Mary Bird Perkins Cancer Center - Covington
Covington, Louisiana, 70433
Northshore Oncology Associates-Covington
Covington, Louisiana, 70433
Mary Bird Perkins Cancer Center - Houma
Houma, Louisiana, 70360
Oncology Center of The South Incorporated
Houma, Louisiana, 70360
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121
Eastern Maine Medical Center
Bangor, Maine, 04401
Lafayette Family Cancer Center-EMMC
Brewer, Maine, 04412
Greater Baltimore Medical Center
Baltimore, Maryland, 21204
TidalHealth Peninsula Regional
Salisbury, Maryland, 21801
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215
Brigham and Women's Hospital
Boston, Massachusetts, 02115
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114
Berkshire Medical Center - Cancer Center
Pittsfield, Massachusetts, 01201
Hickman Cancer Center
Adrian, Michigan, 49221
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, 48106
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109
Bronson Battle Creek
Battle Creek, Michigan, 49017
McLaren Cancer Institute-Bay City
Bay City, Michigan, 48706
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan, 48183
McLaren Cancer Institute-Clarkston
Clarkston, Michigan, 48346
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, 48038
Beaumont Hospital - Dearborn
Dearborn, Michigan, 48124
Ascension Saint John Hospital
Detroit, Michigan, 48236
Henry Ford Hospital
Detroit, Michigan, 48202
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201
Beaumont Hospital - Farmington Hills
Farmington Hills, Michigan, 48336
Weisberg Cancer Treatment Center
Farmington Hills, Michigan, 48334
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
Hurley Medical Center
Flint, Michigan, 48503
McLaren Cancer Institute-Flint
Flint, Michigan, 48532
Singh and Arora Hematology Oncology PC
Flint, Michigan, 48532
Helen DeVos Children's Hospital at Spectrum Health
Grand Rapids, Michigan, 49503
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan, 49503
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, 49503
Allegiance Health
Jackson, Michigan, 49201
Borgess Medical Center
Kalamazoo, Michigan, 49048
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
Karmanos Cancer Institute at McLaren Greater Lansing
Lansing, Michigan, 48910
Sparrow Hospital
Lansing, Michigan, 48912
McLaren Cancer Institute-Lapeer Region
Lapeer, Michigan, 48446
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154
McLaren Cancer Institute-Macomb
Mount Clemens, Michigan, 48043
McLaren Cancer Institute-Central Michigan
Mount Pleasant, Michigan, 48858
Trinity Health Muskegon Hospital
Muskegon, Michigan, 49444
Lakeland Hospital Niles
Niles, Michigan, 49120
Ascension Providence Hospitals - Novi
Novi, Michigan, 48374
McLaren Cancer Institute-Owosso
Owosso, Michigan, 48867
McLaren Cancer Institute-Northern Michigan
Petoskey, Michigan, 49770
21st Century Oncology-Pontiac
Pontiac, Michigan, 48341
Saint Joseph Mercy Oakland
Pontiac, Michigan, 48341
McLaren-Port Huron
Port Huron, Michigan, 48060
Spectrum Health Reed City Hospital
Reed City, Michigan, 49677
William Beaumont Hospital-Royal Oak
Royal Oak, Michigan, 48073
Ascension Saint Mary's Hospital
Saginaw, Michigan, 48601
Lakeland Medical Center Saint Joseph
Saint Joseph, Michigan, 49085
Marie Yeager Cancer Center
Saint Joseph, Michigan, 49085
Ascension Providence Hospitals - Southfield
Southfield, Michigan, 48075
Munson Medical Center
Traverse City, Michigan, 49684
William Beaumont Hospital - Troy
Troy, Michigan, 48085
Saint John Macomb-Oakland Hospital
Warren, Michigan, 48093
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, 48322
University of Michigan Health - West
Wyoming, Michigan, 49519
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota, 56401
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
Mercy Hospital
Coon Rapids, Minnesota, 55433
Essentia Health - Deer River Clinic
Deer River, Minnesota, 56636
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, Minnesota, 56501
Essentia Health Cancer Center
Duluth, Minnesota, 55805
Essentia Health Saint Mary's Medical Center
Duluth, Minnesota, 55805
Miller-Dwan Hospital
Duluth, Minnesota, 55805
Saint Luke's Hospital of Duluth
Duluth, Minnesota, 55805
Fairview Southdale Hospital
Edina, Minnesota, 55435
Lake Region Healthcare Corporation-Cancer Care
Fergus Falls, Minnesota, 56537
Essentia Health - Fosston
Fosston, Minnesota, 56542
Unity Hospital
Fridley, Minnesota, 55432
Essentia Health Hibbing Clinic
Hibbing, Minnesota, 55746
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, 55369
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
Health Partners Inc
Minneapolis, Minnesota, 55454
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
Monticello Cancer Center
Monticello, Minnesota, 55362
Essentia Health - Park Rapids
Park Rapids, Minnesota, 56470
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, 56303
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
Regions Hospital
Saint Paul, Minnesota, 55101
United Hospital
Saint Paul, Minnesota, 55102
Essentia Health Sandstone
Sandstone, Minnesota, 55072
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
Lakeview Hospital
Stillwater, Minnesota, 55082
Essentia Health Virginia Clinic
Virginia, Minnesota, 55792
Ridgeview Medical Center
Waconia, Minnesota, 55387
Rice Memorial Hospital
Willmar, Minnesota, 56201
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
Baptist Cancer Center-Grenada
Grenada, Mississippi, 38901
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi, 38652
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi, 38655
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi, 38671
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri, 63011
Central Care Cancer Center - Bolivar
Bolivar, Missouri, 65613
Parkland Health Center-Bonne Terre
Bonne Terre, Missouri, 63628
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
Southeast Cancer Center
Cape Girardeau, Missouri, 63703
Capital Region Southwest Campus
Jefferson City, Missouri, 65109
Freeman Health System
Joplin, Missouri, 64804
Research Medical Center
Kansas City, Missouri, 64132
University of Kansas Cancer Center - North
Kansas City, Missouri, 64154
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri, 64064
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri, 65401
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
CoxHealth South Hospital
Springfield, Missouri, 65807
Mercy Hospital Springfield
Springfield, Missouri, 65804
Mercy Hospital Saint Louis
St Louis, Missouri, 63141
Mercy Hospital South
St Louis, Missouri, 63128
Missouri Baptist Medical Center
St Louis, Missouri, 63131
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, Missouri, 63127
Billings Clinic Cancer Center
Billings, Montana, 59101
Saint Vincent Healthcare
Billings, Montana, 59101
Bozeman Deaconess Hospital
Bozeman, Montana, 59715
Saint James Community Hospital and Cancer Treatment Center
Butte, Montana, 59701
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana, 59405
Great Falls Clinic
Great Falls, Montana, 59405
Kalispell Regional Medical Center
Kalispell, Montana, 59901
Community Medical Hospital
Missoula, Montana, 59804
CHI Health Saint Francis
Grand Island, Nebraska, 68803
CHI Health Good Samaritan
Kearney, Nebraska, 68847
Nebraska Cancer Research Center
Lincoln, Nebraska, 68510
Nebraska Hematology and Oncology
Lincoln, Nebraska, 68506
Southeast Nebraska Cancer Center - 68th Street Place
Lincoln, Nebraska, 68516
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
Alegent Health Lakeside Hospital
Omaha, Nebraska, 68130
Creighton University Medical Center
Omaha, Nebraska, 68131
Nebraska Cancer Specialists - Omaha
Omaha, Nebraska, 68124
Regional West Medical Center Cancer Center
Scottsbluff, Nebraska, 69361
OptumCare Cancer Care at Seven Hills
Henderson, Nevada, 89052
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89148
GenesisCare USA - Las Vegas
Las Vegas, Nevada, 89109
OptumCare Cancer Care at Charleston
Las Vegas, Nevada, 89102
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada, 89148
OptumCare Cancer Care at MountainView
Las Vegas, Nevada, 89128
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada, 89106
Radiation Oncology Associates
Reno, Nevada, 89509
Renown Regional Medical Center
Reno, Nevada, 89502
Saint Mary's Regional Medical Center
Reno, Nevada, 89503
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
Englewood Hospital and Medical Center
Englewood, New Jersey, 07631
Virtua Samson Cancer Center
Moorestown, New Jersey, 08057
Virtua Memorial
Mount Holly, New Jersey, 08060
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey, 08876
Holy Name Hospital
Teaneck, New Jersey, 07666
Virtua Voorhees
Voorhees Township, New Jersey, 08043
New Mexico Oncology Hematology Consultants
Albuquerque, New Mexico, 87109
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87102
Christus Saint Vincent Regional Cancer Center
Santa Fe, New Mexico, 87505
Northwell Health Imbert Cancer Center
Bay Shore, New York, 11706
Glens Falls Hospital
Glens Falls, New York, 12801
Northwell Health/Center for Advanced Medicine
Lake Success, New York, 11042
North Shore University Hospital
Manhasset, New York, 11030
Garnet Health Medical Center
Middletown, New York, 10940
Long Island Jewish Medical Center
New Hyde Park, New York, 11040
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016
University of Rochester
Rochester, New York, 14642
Staten Island University Hospital
Staten Island, New York, 10305
State University of New York Upstate Medical University
Syracuse, New York, 13210
Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467
Montefiore Medical Center-Einstein Campus
The Bronx, New York, 10461
Montefiore Medical Center-Weiler Hospital
The Bronx, New York, 10461
Atrium Health Stanly/LCI-Albemarle
Albemarle, North Carolina, 28002
Mission Hospital
Asheville, North Carolina, 28801
Atrium Health Pineville/LCI-Pineville
Charlotte, North Carolina, 28210
Atrium Health University City/LCI-University
Charlotte, North Carolina, 28262
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203
Novant Health Presbyterian Medical Center
Charlotte, North Carolina, 28204
Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina, 28025
Novant Health Presbyterian Medical Center Huntersville
Huntersville, North Carolina, 28078
Matthews Radiation Oncology Center
Matthews, North Carolina, 28105
Atrium Health Union/LCI-Union
Monroe, North Carolina, 28112
UNC Rex Healthcare
Raleigh, North Carolina, 27607
Atrium Health Cleveland/LCI-Cleveland
Shelby, North Carolina, 28150
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota, 58103
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
Essentia Health - Jamestown Clinic
Jamestown, North Dakota, 58401
Cleveland Clinic Akron General
Akron, Ohio, 44307
UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio, 44122
Indu and Raj Soin Medical Center
Beavercreek, Ohio, 45431
Cleveland Clinic Mercy Hospital
Canton, Ohio, 44708
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio, 45459
Miami Valley Hospital South
Centerville, Ohio, 45459
Geauga Hospital
Chardon, Ohio, 44024
Bethesda North Hospital
Cincinnati, Ohio, 45242
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio, 45236
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio, 45219
Case Western Reserve University
Cleveland, Ohio, 44106
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
Dayton Physician LLC-Miami Valley Hospital North
Dayton, Ohio, 45415
Good Samaritan Hospital - Dayton
Dayton, Ohio, 45406
Miami Valley Hospital
Dayton, Ohio, 45409
Miami Valley Hospital North
Dayton, Ohio, 45415
Mercy Cancer Center-Elyria
Elyria, Ohio, 44035
Armes Family Cancer Center
Findlay, Ohio, 45840
Blanchard Valley Hospital
Findlay, Ohio, 45840
Orion Cancer Care
Findlay, Ohio, 45840
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066
Dayton Physicians LLC-Atrium
Franklin, Ohio, 45005
Dayton Physicians LLC-Wayne
Greenville, Ohio, 45331
Wayne Hospital
Greenville, Ohio, 45331
Greater Dayton Cancer Center
Kettering, Ohio, 45409
Kettering Medical Center
Kettering, Ohio, 45429
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio, 43537
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, Ohio, 44060
UH Seidman Cancer Center at Southwest General Hospital
Middleburg Heights, Ohio, 44130
University Hospitals Parma Medical Center
Parma, Ohio, 44129
University Hospitals Portage Medical Center
Ravenna, Ohio, 44266
UH Seidman Cancer Center at Firelands Regional Medical Center
Sandusky, Ohio, 44870
Springfield Regional Cancer Center
Springfield, Ohio, 45504
Springfield Regional Medical Center
Springfield, Ohio, 45505
ProMedica Flower Hospital
Sylvania, Ohio, 43560
Mercy Health - Saint Anne Hospital
Toledo, Ohio, 43623
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio, 43606
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio, 43623
Dayton Physicians LLC - Troy
Troy, Ohio, 45373
Upper Valley Medical Center
Troy, Ohio, 45373
University Hospitals Sharon Health Center
Wadsworth, Ohio, 44281
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio, 45069
UH Seidman Cancer Center at Saint John Medical Center
Westlake, Ohio, 44145
UHHS-Westlake Medical Center
Westlake, Ohio, 44145
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma, 73505
Integris Cancer Institute of Oklahoma
Oklahoma City, Oklahoma, 73142
Integris Southwest Medical Center
Oklahoma City, Oklahoma, 73109
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Legacy Mount Hood Medical Center
Gresham, Oregon, 97030
Kaiser Permanente Northwest
Portland, Oregon, 97227
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon, 97210
Jefferson Abington Hospital
Abington, Pennsylvania, 19001
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania, 18017
Crozer-Keystone Regional Cancer Center at Broomall
Broomall, Pennsylvania, 19008
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317
Geisinger Medical Center
Danville, Pennsylvania, 17822
Northeast Radiation Oncology Center
Dunmore, Pennsylvania, 18512
Pocono Medical Center
East Stroudsburg, Pennsylvania, 18301
Saint Vincent Hospital
Erie, Pennsylvania, 16544
Crozer Regional Cancer Center at Brinton Lake
Glen Mills, Pennsylvania, 19342
Jefferson Hospital
Jefferson Hills, Pennsylvania, 15025
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837
Lewistown Hospital
Lewistown, Pennsylvania, 17044
Forbes Hospital
Monroeville, Pennsylvania, 15146
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111
Temple University Hospital
Philadelphia, Pennsylvania, 19140
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
Geisinger Medical Oncology-Selinsgrove
Selinsgrove, Pennsylvania, 17870
Grand View Hospital
Sellersville, Pennsylvania, 18960
Reading Hospital
West Reading, Pennsylvania, 19611
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania, 19090
Lankenau Medical Center
Wynnewood, Pennsylvania, 19096
AnMed Health Cancer Center
Anderson, South Carolina, 29621
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316
Medical University of South Carolina
Charleston, South Carolina, 29425
Gibbs Cancer Center-Gaffney
Gaffney, South Carolina, 29341
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605
Gibbs Cancer Center-Pelham
Greer, South Carolina, 29651
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650
Levine Cancer Institute-Rock Hill
Rock Hill, South Carolina, 29732
Rock Hill Radiation Therapy Center
Rock Hill, South Carolina, 29730
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672
Spartanburg Medical Center
Spartanburg, South Carolina, 29303
MGC Hematology Oncology-Union
Union, South Carolina, 29379
Avera Cancer Institute-Aberdeen
Aberdeen, South Dakota, 57401
Avera Cancer Institute
Sioux Falls, South Dakota, 57105
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
Memorial Hospital
Chattanooga, Tennessee, 37404
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee, 38017
The West Clinic - Wolf River
Germantown, Tennessee, 38138
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, 38120
The West Clinic - Mid-Town
Memphis, Tennessee, 38104
University of Tennessee Health Science Center
Memphis, Tennessee, 38163
Vanderbilt Breast Center at One Hundred Oaks
Nashville, Tennessee, 37204
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232
Saint Joseph Regional Cancer Center
Bryan, Texas, 77802
Baylor University Medical Center
Dallas, Texas, 75246
Parkland Memorial Hospital
Dallas, Texas, 75235
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
University of Texas Medical Branch
Galveston, Texas, 77555-0565
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030
Ben Taub General Hospital
Houston, Texas, 77030
M D Anderson Cancer Center
Houston, Texas, 77030
UTMB Cancer Center at Victory Lakes
League City, Texas, 77573
Covenant Medical Center-Lakeside
Lubbock, Texas, 79410
Scott and White Memorial Hospital
Temple, Texas, 76508
Sandra L Maxwell Cancer Center
Cedar City, Utah, 84720
Logan Regional Hospital
Logan, Utah, 84321
Intermountain Medical Center
Murray, Utah, 84107
McKay-Dee Hospital Center
Ogden, Utah, 84403
Utah Valley Regional Medical Center
Provo, Utah, 84604
Riverton Hospital
Riverton, Utah, 84065
LDS Hospital
Salt Lake City, Utah, 84143
Utah Cancer Specialists-Salt Lake City
Salt Lake City, Utah, 84106
Saint George Regional Medical Center
St. George, Utah, 84770
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners, Vermont, 05602
University of Vermont and State Agricultural College
Burlington, Vermont, 05405
University of Vermont Medical Center
Burlington, Vermont, 05401
Norris Cotton Cancer Center-North
Saint Johnsbury, Vermont, 05819
Sentara Cancer Institute at Sentara CarePlex Hospital
Hampton, Virginia, 23666
Sentara Leigh Hospital
Norfolk, Virginia, 23502
Sentara Norfolk General Hospital
Norfolk, Virginia, 23507
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, 23298
MultiCare Auburn Medical Center
Auburn, Washington, 98001
Overlake Medical Center
Bellevue, Washington, 98004
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton, Washington, 98310
Harrison Medical Center
Bremerton, Washington, 98310
Highline Medical Center-Main Campus
Burien, Washington, 98166
Virginia Mason Federal Way Medical Center
Federal Way, Washington, 98002
MultiCare Gig Harbor Medical Park
Gig Harbor, Washington, 98335
Tacoma/Valley Radiation Oncology Centers-Gig Harbor
Gig Harbor, Washington, 98332
Tri-Cities Cancer Center
Kennewick, Washington, 99336
Seattle Cancer Care Alliance at EvergreenHealth
Kirkland, Washington, 98034
Skagit Regional Health Cancer Care Center
Mount Vernon, Washington, 98274
Skagit Valley Hospital
Mount Vernon, Washington, 98274
MultiCare Good Samaritan Hospital
Puyallup, Washington, 98372
Tacoma/Valley Radiation Oncology Centers-Puyallup
Puyallup, Washington, 98372
Valley Medical Center
Renton, Washington, 98055
FHCC at Northwest Hospital
Seattle, Washington, 98133
FHCC South Lake Union
Seattle, Washington, 98109
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109
University of Washington Medical Center - Montlake
Seattle, Washington, 98195
Virginia Mason Medical Center
Seattle, Washington, 98101
Spokane Valley Cancer Center-Mayfair
Spokane, Washington, 99208
MultiCare Tacoma General Hospital
Tacoma, Washington, 98405
Northwest Medical Specialties PLLC
Tacoma, Washington, 98405
Tacoma/Valley Radiation Oncology Centers-Saint Joe's
Tacoma, Washington, 98405
Legacy Salmon Creek Hospital
Vancouver, Washington, 98686
Wenatchee Valley Hospital and Clinics
Wenatchee, Washington, 98801
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, 98902
United Hospital Center
Bridgeport, West Virginia, 26330
West Virginia University Charleston Division
Charleston, West Virginia, 25304
West Virginia University Healthcare
Morgantown, West Virginia, 26506
Camden Clark Medical Center
Parkersburg, West Virginia, 26101
Wheeling Hospital/Schiffler Cancer Center
Wheeling, West Virginia, 26003
Duluth Clinic Ashland
Ashland, Wisconsin, 54806
Northwest Wisconsin Cancer Center
Ashland, Wisconsin, 54806
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin, 53105
Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire, Wisconsin, 54701
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
Aurora Health Center-Fond du Lac
Fond du Lac, Wisconsin, 54937
Aurora Health Care Germantown Health Center
Germantown, Wisconsin, 53022
Aurora Cancer Care-Grafton
Grafton, Wisconsin, 53024
Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311
UW Cancer Center Johnson Creek
Johnson Creek, Wisconsin, 53038
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, 53142
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, 53792
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, 54143
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin, 53051
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin, 53209
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215
Aurora Sinai Medical Center
Milwaukee, Wisconsin, 53233
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin, 54548
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, 54904
Aurora Cancer Care-Racine
Racine, Wisconsin, 53406
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, 53081
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482
Aurora Medical Center in Summit
Summit, Wisconsin, 53066
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, 54241
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, 53188
Marshfield Clinic-Wausau Center
Wausau, Wisconsin, 54401
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin, 53226
Aurora West Allis Medical Center
West Allis, Wisconsin, 53227
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin, 53095
Diagnostic and Treatment Center
Weston, Wisconsin, 54476
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476

Fuente Oficial

Ver en ClinicalTrials.gov