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NCT03998202

Miopatía y mecanismos de toxicidad de la quimioterapia en adultos mayores con cáncer colorrectal.

Reclutando

Descripción

Este estudio examinará la asociación entre la baja masa muscular (miopenia) en el momento del diagnóstico y la toxicidad de la quimioterapia en adultos mayores con cáncer colorrectal avanzado de reciente diagnóstico.

Evidencia de la diana molecular en cáncer colorrectal

Aún no hay evidencia documentada en nuestra base para la diana o el fármaco de este ensayo. Esta sección crece a medida que se procesan nuevas publicaciones.

Criterios de Elegibilidad

Criterios de inclusión:

  • Cáncer colorrectal metastásico de reciente diagnóstico o recurrencia metastásica de cáncer colorrectal con al menos 3 meses (12 semanas) desde la finalización del tratamiento del cáncer colorrectal no metastásico.
  • Pacientes que planean someterse o que han comenzado recientemente a recibir inmunoterapia y/o quimioterapia basada en 5-FU como tratamiento de primera línea. La quimioterapia con 5-FU puede ser 5-FU solo o en combinación con oxaliplatino y/o irinotecán +/- inmunoterapia. También se acepta capecitabina.
  • Esperanza de vida estimada \>= 6 meses.
  • Los pacientes deben ser capaces de comprender el inglés o el español (para completar el cuestionario).
  • Capacidad para comprender y disposición para firmar un documento de consentimiento informado por escrito.
  • La elegibilidad del paciente no depende del IMC o del peso. Los pacientes con un cambio significativo (+- \> 10 %) en el peso corporal en los últimos 12 meses son elegibles para este estudio.

Criterios de exclusión:

  • Pacientes inscritos en cuidados paliativos.
  • Quimioterapia sistémica previa para el cáncer colorrectal metastásico (aceptable si la quimioterapia adyuvante se completó hace al menos 3 meses (12 semanas) antes de esta recurrencia y tratamiento).
  • Los pacientes no pueden estar recibiendo ningún otro agente experimental.
  • No se permiten metástasis cerebrales no tratadas. Los pacientes con metástasis cerebrales tratadas son elegibles.
  • Pacientes que están recibiendo o que planean someterse a radioterapia en un futuro próximo.

Información del Ensayo

NCT03998202
Reclutando
Sin fase definida
300 participantes
Sep 2019
Dic 2026

Ubicaciones146

United States (146)
The University of Iowa - Ankeny
Ankeny
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor
Duluth Clinic Ashland
Ashland
Louisiana Hematology Oncology Associates LLC
Baton Rouge
Mary Bird Perkins Cancer Center
Baton Rouge
MBP Cancer Center - Baton Rouge General
Baton Rouge
Sanford Joe Lueken Cancer Center
Bemidji
Sanford Bismarck Medical Center
Bismarck
Illinois CancerCare-Bloomington
Bloomington
Prisma Health Cancer Institute - Spartanburg
Boiling Springs
Essentia Health Saint Joseph's Medical Center
Brainerd
Trinity Health IHA Medical Group Hematology Oncology-Brighton
Brighton
Trinity Health Medical Center-Brighton
Brighton
Illinois CancerCare-Canton
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton
Trinity Health Medical Center - Canton
Canton
Saint Francis Medical Center
Cape Girardeau
Saint Anthony Regional Hospital
Carroll
SIH Cancer Institute
Carterville
Oncology Associates at Mercy Medical Center
Cedar Rapids
Physicians' Clinic of Iowa PC
Cedar Rapids
Atrium Health Pineville/LCI-Pineville
Charlotte
Atrium Health University City/LCI-University
Charlotte
Carolinas Medical Center/Levine Cancer Institute
Charlotte
Levine Cancer Institute-SouthPark
Charlotte
Chelsea Hospital
Chelsea
Trinity Health IHA Hematology Oncology Consultants-Chelsea Hospital
Chelsea
John H Stroger Jr Hospital of Cook County
Chicago
Adena Regional Medical Center
Chillicothe
Wake Forest University at Clemmons
Clemmons
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive
John B Amos Cancer Center
Columbus
The Mark H Zangmeister Center
Columbus
Atrium Health Cabarrus/LCI-Concord
Concord
Mercy Hospital
Coon Rapids
Carle at The Riverfront
Danville
Geisinger Medical Center
Danville
Cancer Care Specialists of Illinois - Decatur
Decatur
Essentia Health - Deer River Clinic
Deer River
Broadlawns Medical Center
Des Moines
Iowa Methodist Medical Center
Des Moines
Mercy Medical Center - Des Moines
Des Moines
The University of Iowa-Des Moines
Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes
Essentia Health Cancer Center
Duluth
Prisma Health Cancer Institute - Easley
Easley
Marshfield Medical Center-EC Cancer Center
Eau Claire
Fairview Southdale Hospital
Edina
Crossroads Cancer Center
Effingham
Essentia Health Cancer Center-South University Clinic
Fargo
Sanford Broadway Medical Center
Fargo
Sanford Roger Maris Cancer Center
Fargo
Parkland Health Center - Farmington
Farmington
Armes Family Cancer Center
Findlay
Cancer Hematology Centers - Flint
Flint
Genesee Hematology Oncology PC
Flint
Genesys Hurley Cancer Institute
Flint
UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge
Gibbs Cancer Center-Gaffney
Gaffney
Illinois CancerCare-Galesburg
Galesburg
Levine Cancer Institute-Gaston
Gastonia
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay
Saint Vincent Hospital Cancer Center Green Bay
Green Bay
Prisma Health Cancer Institute - Butternut
Greenville
Prisma Health Cancer Institute - Eastside
Greenville
Prisma Health Cancer Institute - Faris
Greenville
Self Regional Healthcare
Greenwood
Gibbs Cancer Center-Pelham
Greer
Prisma Health Cancer Institute - Greer
Greer
Geisinger Medical Center-Cancer Center Hazleton
Hazleton
Essentia Health Hibbing Clinic
Hibbing
Terrebonne General Medical Center
Houma
Marshfield Medical Center Dickinson
Iron Mountain
Geisinger Medical Oncology-Lewisburg
Lewisburg
Lewistown Hospital
Lewistown
Saint Joseph Hospital East
Lexington
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia
Minnesota Oncology Hematology PA-Maplewood
Maplewood
Saint John's Hospital - Healtheast
Maplewood
Marshfield Medical Center-Marshfield
Marshfield
Carle Physician Group - Mattoon/Charleston
Mattoon
Beebe South Coastal Health Campus
Millville
Abbott-Northwestern Hospital
Minneapolis
Health Partners Inc
Minneapolis
Marshfield Medical Center - Minocqua
Minocqua
Knox Community Hospital
Mount Vernon
SSM Health Good Samaritan
Mount Vernon
New Ulm Medical Center
New Ulm
Helen F Graham Cancer Center
Newark
Licking Memorial Hospital
Newark
Medical Oncology Hematology Consultants PA
Newark
Carle BroMenn Medical Center
Normal
Carle Cancer Institute Normal
Normal
Cancer Care Center of O'Fallon
O'Fallon
Illinois CancerCare-Ottawa Clinic
Ottawa
Essentia Health - Park Rapids
Park Rapids
Illinois CancerCare-Pekin
Pekin
Illinois CancerCare-Peoria
Peoria
Illinois CancerCare-Peru
Peru
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac
Southern Ohio Medical Center
Portsmouth
Geisinger Cancer Services-Pottsville
Pottsville
Corewell Health Reed City Hospital
Reed City
Beebe Health Campus
Rehoboth Beach
Marshfield Medical Center-Rice Lake
Rice Lake
Mercy Clinic-Rolla-Cancer and Hematology
Rolla
Heartland Regional Medical Center
Saint Joseph
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park
Regions Hospital
Saint Paul
United Hospital
Saint Paul
Sainte Genevieve County Memorial Hospital
Sainte Genevieve
Essentia Health Sandstone
Sandstone
Community Medical Center
Scranton
Geisinger Medical Oncology-Selinsgrove
Selinsgrove
Prisma Health Cancer Institute - Seneca
Seneca
Saint Francis Regional Medical Center
Shakopee
Sanford Cancer Center Oncology Clinic
Sioux Falls
Sanford USD Medical Center - Sioux Falls
Sioux Falls
Spartanburg Medical Center
Spartanburg
Essentia Health-Spooner Clinic
Spooner
CoxHealth South Hospital
Springfield
Mercy Hospital Springfield
Springfield
Southern Illinois University School of Medicine
Springfield
Springfield Clinic
Springfield
Springfield Regional Cancer Center
Springfield
Missouri Baptist Medical Center
St Louis
Geisinger Medical Group
State College
Marshfield Medical Center-River Region at Stevens Point
Stevens Point
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay
Missouri Baptist Sullivan Hospital
Sullivan
BJC Outpatient Center at Sunset Hills
Sunset Hills
MGC Hematology Oncology-Union
Union
Carle Cancer Center
Urbana
Essentia Health Virginia Clinic
Virginia
Illinois CancerCare - Washington
Washington
MedStar Georgetown University Hospital
Washington D.C.
Marshfield Medical Center - Weston
Weston
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre
Wake Forest Baptist Health - Wilkes Medical Center
Wilkesboro
Rice Memorial Hospital
Willmar
Christiana Care Health System-Wilmington Hospital
Wilmington
Wake Forest University Health Sciences
Winston-Salem
University of Michigan Health - West
Wyoming
Trinity Health IHA Medical Group Hematology Oncology -Ann Arbor
Ypsilanti
Genesis Healthcare System Cancer Care Center
Zanesville

Fuente Oficial

Ver en ClinicalTrials.gov