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NCT05253651

Un estudio de tucatinib en combinación con trastuzumab y mFOLFOX6 frente al tratamiento estándar en el cáncer colorrectal metastásico HER2+ en primera línea.

Reclutando Fase 3

Descripción

Este estudio se realiza para determinar si tucatinib, en combinación con otros fármacos contra el cáncer, es más eficaz que el tratamiento estándar para pacientes con cáncer colorrectal HER2 positivo. Este estudio también determinará qué efectos secundarios se producen cuando los participantes toman esta combinación de fármacos. Un efecto secundario es cualquier efecto que un fármaco tenga en el organismo, aparte de tratar la enfermedad.

Los participantes en este estudio tienen cáncer colorrectal que se ha extendido por todo el organismo (metastásico) y/o que no puede ser extirpado mediante cirugía (irresecable).

Los participantes se asignarán aleatoriamente al grupo de tucatinib o al grupo de tratamiento estándar. El grupo de tucatinib recibirá tucatinib, trastuzumab y mFOLFOX6. El grupo de tratamiento estándar recibirá:

* mFOLFOX6 solo,
* mFOLFOX6 con bevacizumab, o
* mFOLFOX6 con cetuximab.

mFOLFOX6 es una combinación de varios fármacos. Todos los fármacos que se administran en este estudio se utilizan para tratar este tipo de cáncer.

Evidencia de la diana molecular en cáncer colorrectal (HER2)

Fármaco / régimen ORR SLP (m) Fase / n Evidencia Fuente
Trastuzumab + Pertuzumab este fármaco 34.6% 4.7 Phase 2 / n=26 2A PMID 39761503 · 2025
Trastuzumab + Pertuzumab este fármaco 57.1% 9.9 Phase 2 2A PMID 39761503 · 2025
Trastuzumab + Pertuzumab este fármaco 9.1% 3 Phase 2 2A PMID 39761503 · 2025
Trastuzumab Deruxtecan (T-DXd) este fármaco 37.8% 5.8 Phase 2 / n=122 2A PMID 39116902 · 2024
Trastuzumab Deruxtecan este fármaco 36.6% 5.8 Phase 2 / n=122 2A PMID 37354553 · 2023
Tucatinib + Trastuzumab este fármaco 38.1% 8.2 Phase 2 / n=84 2A PMID 37142372 · 2023

Criterios de Elegibilidad

Criterios de inclusión:

  • Adenocarcinoma de colon o recto confirmado histológica y/o citológicamente, que sea localmente avanzado, no susceptible de resección o metastásico.
  • Capacidad para proporcionar los bloques de tejido tumoral fijados en formalina y embebidos en parafina (FFPE) más recientes disponibles (o láminas recién obtenidas) obtenidos antes del inicio del tratamiento y enviados a un laboratorio central.
  • Si no se dispone de tejido de archivo, se requiere una biopsia basal recién obtenida de una lesión tumoral accesible en los 35 días previos al inicio del tratamiento del estudio.
  • Enfermedad HER2+ determinada mediante un ensayo basado en tejido realizado en un laboratorio central.
  • El participante debe tener una enfermedad con el gen del oncógeno homólogo del sarcoma viral de rata en estado salvaje (RAS WT), según lo determinado por pruebas locales o centrales. Para el análisis central de RAS, la muestra de tejido debe analizarse dentro de los 12 meses posteriores a la fecha de la biopsia.
  • Enfermedad radiográficamente medible según RECIST v1.1 con:
  • Al menos un sitio de enfermedad que sea medible y que no haya sido irradiado previamente, o
  • Si el participante ha recibido radiación previa en la(s) lesión(es) objetivo(s), debe haber evidencia de progresión desde la radiación.
  • Estado funcional del Grupo de Oncología Cooperativa del Este (ECOG) de 0 o 1.
  • Inclusión en el SNC: según la resonancia magnética cerebral con contraste, los participantes pueden tener cualquiera de los siguientes:
  • Sin evidencia de metástasis cerebrales.
  • Metástasis cerebrales tratadas previamente que sean asintomáticas.

Criterios de exclusión:

  • Terapia sistémica antitumoral previa para el cáncer colorrectal (CRC) en el entorno localmente avanzado, no susceptible de resección o metastásico; tenga en cuenta que los participantes pueden haber recibido un máximo de 2 dosis de mFOLFOX6 en el entorno localmente avanzado/no susceptible de resección o metastásico antes de la aleatorización.
  • Nota: Puede haber recibido quimioterapia para el CRC en el entorno adyuvante si se completó hace más de 6 meses antes de la inclusión.
  • Radioterapia dentro de los 14 días previos a la inclusión (o dentro de los 7 días en el entorno de la radiocirugía estereotáctica).
  • Tratamiento previo con terapia anti-HER2.
  • Neuropatía activa o no tratada de grado 3 o superior.
  • Perforación gastrointestinal (GI) activa o no tratada en el momento del cribado.

Información del Ensayo

NCT05253651
Reclutando
Fase 3
400 participantes
Oct 2022
Dic 2027

Ubicaciones366

Argentina (6)
Instituto Medico Especializado Alexander Fleming
Buenos Aires
Hospital Britanico de Buenos Aires
CABA
CEMAIC - Centro Medico Privado
Córdoba
IONC Instituto Oncologico de Cordoba Fundacion Richardet Longo
Córdoba
Centro de Investigacion Pergamino SA
Pergamino
Instituto Medico de la Fundacion Estudios Clinicos
Rosario
Australia (3)
Chris O'Brien Lifehouse
Camperdown
St Vincent's Hospital
Fitzroy
Princess Alexandra Hospital
Woolloongabba
Austria (5)
Uniklinikum Salzburg, Landeskrankenhaus
Salzburg
AKH - Medizinische Universitat Wien
Vienna
Klinikum Wels-Grieskirchen GmbH Austria
Wels
Klinikum Wels-Grieskirchen GmbH Austria
Wels
Landesklinikum Wiener Neustadt
Wiener Neustadt
Belgium (8)
Institut Jules Bordet
Anderlecht
Cliniques Universitaires Saint-Luc
Brussels
UZA
Edegem
CHU HELORA - Hopital de Jolimont
Haine-Saint-Paul
Universitair Ziekenhuis Leuven
Leuven
Centre Hospitalier Chretien - Clinique MontLegia
Liège
Maag-,Darm- en Leverziekten AZ Turnhout
Turnhout
Oncologisch Dagziekenhuis AZ Turnhout Campus Sint-Elisabeth
Turnhout
Brazil (10)
Instituto De Educação, Pesquisa e Gestão em Saúde - Instituto Américas
Barra da Tijuca
Hospital de Cancer de Barretos/Fundacao Pio XII
Barretos
CIONC-Centro Integrado de Oncologia de Curitiba
Curitiba
Centro de Pesquisas Clinicas da Fundação Doutor Amaral Carvalho
Jaú
Centro Integrado de Pesquisa em Oncologia CIPO-GHC / Hospital Nossa Senhora da Conceicao
Porto Alegre
Institute de Educacao, Pesquisa e Gestao em Saude - Instituto COI
Rio de Janeiro
Institute de Educacao, Pesquisa e Gestao em Saude - Instituto COI
Rio de Janeiro
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia.
Santo André
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira.
São Paulo
Canada (5)
Jewish General Hospital
Montreal
The Ottawa Hospital Cancer Centre
Ottawa
Saskatoon Cancer Centre
Saskatoon
Mount Sinai Hospital
Toronto
Sunnybrook Research Institute
Toronto
Chile (3)
Biocenter
Concepción
Centro de estudios clinicos SAGA
Santiago
Oncocentro Apys
Viña del Mar
China (30)
Beijing Cancer Hospital
Beijing
Hunan Cancer Hospital
Changsha
The Second Xiangya Hospital of Central South University
Changsha
The First People's Hospital of Changzhou
Changzhou
Affiliated Hospital of Chengde Medical University
Chengde
Affiliated Hospital of Chengde Medical University
Chengde
Army Specialty Medical Center of The Chinese People's Liberation Army
Chongqing
Fujian Medical University Union Hospital
Fuzhou
The Sixth Affiliated hospital, Sun Yat-sen University
Guangzhou
The Second Affiliated Hospital of Hainan Medical University
Haikou
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou
Harbin Medical University Cancer Hospital
Harbin
Jinan Central Hospital
Jinan
Shandong Cancer Hospital
Jinan
The First Affiliated Hospital of Jinzhou Medical University
Jinzhou
The First Hospital of Lanzhou University
Lanzhou
LinYi Cancer Hospital
Linyi
Meizhou People's hospital
Meizhou
The First Affiliated Hospital of Nanchang University
Nanchang
Nanyang Second General Hospital
Nanyang
Shanghai General Hospital
Shanghai
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai
Liaoning Cancer Hospital & Institute
Shenyang
The First Affiliated Hospital of Suzhou University
Suzhou
Shanxi Province Cancer Hospital
Taiyuan
Tangshan People's Hospital
Tangshan
Hubei Cancer Hospital
Wuhan
Xuzhou Central Hospital
Xuzhou
Henan Provincial People's Hospital
Zhengzhou
France (20)
Institut Sainte Catherine
Avignon
Centre Hospitalier Regional et Universitaire de Besancon - Hopital Jean-Minjoz
Besançon
CHU Brest Hopital Cavale Blanche
Brest
CHU Estaing
Clermont-Ferrand
Hopital Henri Mondor
Créteil
Center Georges-Francois Leclerc
Dijon
Hopital Edouard Herriot
Lyon
Höpital Saint-Joseph
Marseille
Centre Hospitalier Universitaire Nantes-Hotel Dieu
Nantes
Centre Antoine Lacassagne
Nice
Hopital Europeen Georges Pompidou
Paris
Hopital Saint-Antoine
Paris
Hopital Saint-Louis
Paris
CHU Bordeaux Hopital Haut Leveque
Pessac
CHU Poitiers
Poitiers
CHU de Rouen
Rouen
Institut de Cancérologie de l'Ouest - Saint-Herblain
Saint-Herblain
Centre Hospitalier Universitaire Sainte-Etienne - Hopital Nord
Saint-Priest-en-Jarez
Institut de Cancerologie Strasbourg Europe
Strasbourg
CHU Toulouse-Rangueil
Toulouse
Germany (16)
Klinikum St. Marien Amberg
Amberg
Charité - Universitätsmedizin Berlin
Berlin
Charité - Universitätsmedizin Berlin Campus Virchiow-Klinikum Zentralapotheke
Berlin
Klinikum Chemnitz gGmbH
Chemnitz
Gemeinschaftspraxis Hämatologie - Onkologie
Dresden
Technische Universität Dresden, Medizinische Fakultät Carl Gustav Carus
Dresden
Asklepios Kliniken Hamburg GmbH
Hamburg
Asklepios Tumorzentrum Hamburg, Asklepios Klinik Altona
Hamburg
Hämatologisch Onkologische Praxis Eppendorf (HOPE)
Hamburg
Medizinische Hochschule Hannover (MHH)
Hanover
Medizinische Hochschule Hannover (MHH)
Hanover
Universitätsklinikum Leipzig
Leipzig
Klinikum rechts der Isar der Technischen Universitaet Muenchen
München
LMU Klinikum - Campus Großhadern
München
CCC Muenchen TUM
Munich
Universitaetsklinikum Ulm
Ulm
Greece (5)
Athens Medical Center - Psychikon branch
Athens
Evgenidion Clinic Agia Trias Oncology Department
Athens
University General Hospital "Attikon"
Athens
"University General Hospital of Heraklion Oncology Unit "
Heraklion
"Papageorgiou" General Hospital of Thessaloniki 2nd Internal Medicine/Oncology Clinic of Aristotle
Nea Efkarpia
Ireland (7)
Bon Secours Hospital
Cork
Cork University Hospital,Department of Medical Onncology
Cork
Beaumont Hospital
Dublin
Mater Misericordiae University Hospital
Dublin
Mater Private Hospital
Dublin
St Vincents University Hospital
Dublin
University Hospital Waterford
Waterford
Italy (23)
UOC Oncologia Medica - Dipartimento Onco Ematologico AORN San Giuseppe Moscati di Avellino
Avellino
Fondazione Poliambulanza Istituto Ospedaliero
Brescia
UOC Oncologia Medica, ARNAS GARIBALDI - PRESIDIO OSPEDALIERO NESIMA
Catania
SODc Oncologia Medica e Clinica, AOU Careggi
Florence
Struttura Semplice Dipartimentale di Oncologia Medica e Terapia Biomolecolare Azienda Ospedaliero
Foggia
IRCCS Azienda Ospedaliera Metropolitana (IRCCS AOM)
Genova
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan
lstituto Europeo di Oncologia
Milan
Niguarda Cancer Center Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan
Azienda Ospedaliera Universitaria Cagliari
Monserrato
Farmacia AOU Cagliari - Presidio Ospedaliero ' Duilio Casula' di Monserrate
Monserrato
UOC Oncoematologia
Naples
A.O.U. San Luigi Gonzaga
Orbassano
Istituto Oncologico Veneto - IRCCS
Padova
Fondazione IRCCS Policlinico San Matteo
Pavia
Azienda Ospedaliero Universitaria Pisana
Pisa
S.C Oncologia Arcispedale Santa Maria Nuova
Reggio Emilia
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome
ASST della Valtellina e dell'alto Lario - Presidio Ospedaliero di Sondrio
Sondrio
UOC Oncologia, Azienda Ospedaliera Cardinale Giovanni Panico
Tricase
Centro ricerche cliniche di Verona SRL
Verona
Servizio Farmacia Azienda Ospedaliera Universitaria lntegrata (AOUI) di Verona
Verona
U.O.C. Oncologia Azienda Ospedaliera Universitaria lntegrata (AOUI) di Verona
Verona
Japan (18)
Chiba Cancer Center
Chiba
National Cancer Center Hospital
Chuo-Ku
National Hospital Organization Kyushu Cancer Center
Fukuoka
National Cancer Center Hospital East
Kashiwa-shi
St. Marianna University Hospital
Kawasaki-shi
Kagawa University Hospital
Kita-gun
Saitama Cancer Center
Kitaadachi-gun
Kobe City Hospital Organization Kobe City Medical Center General Hospital
Kobe
Cancer Institute Hospital of JFCR
Koto-ku
NHO Shikoku Cancer Center
Matsuyama
National Hospital Organization Osaka National Hospital
Osaka
Osaka General Medical Center
Osaka
Kindai University Hospital
Osakasayama-shi
Kindai University Hospital
Sakai
Hokkaido University Hospital
Sapporo
The University of Osaka Hospital
Suita
Osaka Medical and Pharmaceutical University Hospital
Takatsuki-shi
Kanagawa Cancer Center
Yokohama
Netherlands (4)
Netherlands Cancer Institute
Amsterdam
Klinische Farmacie
Nieuwegein
St. Antonius Ziekenhuis - Ziekenhuis Utrecht
Utrecht
Viecuri Medisch Centrum
Venlo
Norway (3)
Helse Bergen HF, Haukeland University Hospital
Bergen
Sjukehusapoteket i Bergen [Bergen Hospital Pharmacy]
Bergen
Oslo University Hospital (OUH) - The Norwegian Radium Hospital
Oslo
Poland (11)
Apteka Szpitalna Uniwersytie Centrum Kliniczne
Gdansk
Klinika Onkologii i Radioterapii Uniwersyteckie Centrum Kliniczne.
Gdansk
Przychodnia Lekarska KOMED Roman Karaszewski
Konin
Salve Medica
Lodz
Salve Medica Apteka Szpitalna
Lodz
MRUK-MED | Sp. z.o.o
Rzeszów
MRUK-MED | Sp. z.o.o Apteka szpitalna
Rzeszów
Marii Sklodowskiej-Curie Panstwowy lnstytut Badawczy
Warsaw
Narodowy lnstytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy lnstytut Badawczy
Warsaw
Wojskowy Instytut Medyczny
Warsaw
Wojskowy Instytut Medyczny Klinika Onkologii
Warsaw
Portugal (4)
Hospital Garcia de Orta
Almada
Unidade Local de Saude da Guarda-Hospital Sousa Martins
Guarda
Fundacao Champalimaud
Lisbon
Centro Hospitalar Universitário de Santo Antonio,E.P.E.
Porto
Slovakia (2)
Narodny Onkologicky ustav II.Onkologicka Klinika LFUK a NOU
Bratislava
Narodny onkologicky ustav nemocnica lekaren
Bratislava
South Korea (7)
Gachon University Gil Medical Center
Incheon
Asan Medical Center
Seoul
Korea University Anam Hospital
Seoul
Korea University Guro Hospital
Seoul
Samsung Medical Center
Seoul
Seoul National University Hospital
Seoul
Severance Hospital, Yonsei University Health System
Seoul
Spain (24)
Hospital General Universitario de Alicante
Alicante
CETIR Viladomat
Barcelona
Data review: Vall d'Hebron institute of Oncology (VHIO).
Barcelona
Hospital Clinic de Barcelona
Barcelona
Hospital Vall d'Hebron
Barcelona
Hospital Vall d'Hebron Unidad de Farmacia de Ensayos Clinicos Oncohematologia
Barcelona
Radiology: CETIR Ascires
Barcelona
Hospital Universitario Reina Sofia
Córdoba
Hospital Duran i Reynals - Institut Catala d'Oncologia L'Hospitalet (ICO L'Hospitalet)
L'Hospitalet de Llobregat
Hospital Universitari Arnau de Vilanova
Lleida
Hospital General Universitario Gregorio Maranon
Madrid
Hospital Universitario 12 de Octubre
Madrid
Hospital Universitario La Paz
Madrid
Hospital Universitario Ramon y Cajal
Madrid
Hospital Regional Universitario de Malaga (Hospital Civil)
Málaga
Complejo Hospitalario Universitario de Ourense
Ourense
Hospital Universitario Central de Asturias
Oviedo
Complejo Hospitalario de Navarra
Pamplona
Complejo Hospitalario Universitario de Canarias
San Cristóbal de La Laguna
Hospital Universitario Marques de Valdecilla
Santander
Hospital Universitario Virgen del Rocio
Seville
Hospital General Universitario de Valencia
Valencia
Hospital Quiron Salud Zaragoza
Zaragoza
Hospital Universitario Miguel Servet
Zaragoza
Switzerland (2)
Zuripharm AG
Schlieren
Universitatsspital Zurich - Klinik fur Medizinische Onkologie und Hamatologie USZ
Zurich
Taiwan (6)
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City
National Cheng Kung University Hospital
Tainan
National Taiwan University Hospital
Taipei
National Taiwan University Hospital Clinical Trial Pharmacy
Taipei
Taipei Veterans General Hospital
Taipei
Chang Gung Memorial Hospital LinKou
Taoyuan
United Kingdom (12)
University Hospitals Bristol and Weston NHS Foundation Trust
Bristol
Cambridge University Hospitals NHS Foundation Trust, Oncology Centre
Cambridge
NHS Greater Glasgow & Clyde - Beatson West of Scotland Cancer Care
Glasgow
Leeds Teaching Hospitals NHS Trust, st James's Institute of Oncology
Leeds
Guy's and Saint Thomas' NHS Foundation Trust
London
Imperial College Healthcare NHS Trust
London
The Royal Marsden Hospital - Chelsea Site
London
The Royal Marsden NHS Foundation Trust
London
The Christie NHS Foundation Trust
Manchester
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne
The Royal Marsden Hospital
Sutton
United States (132)
Kaiser Permanente Anaheim Kraemer Medical Offices
Anaheim
Los Angeles Cancer Network - Anaheim
Anaheim
Emory Saint Joseph's Hospital
Atlanta
Emory University Hospital
Atlanta
Emory University Hospital Midtown
Atlanta
Winship Cancer Institute
Atlanta
Rocky Mountain Cancer Centers, LLP
Aurora
Mount Sinai Medical Center Aventura ER
Aventura
Kaiser Permanente Baldwin Park Medical Center
Baldwin Park
MSK Basking Ridge
Basking Ridge
UPMC Hillman Cancer Center - Beaver
Beaver
Kaiser Permanente Bellflower Medical Offices
Bellflower
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care
Blacksburg
Rocky Mountain Cancer Centers, LLP
Boulder
Minnesota Oncology Hematology, PA
Burnsville
UPMC Hillman Cancer Center at Butler Health System
Butler
Gabrail Cancer Center Research
Canton
Rocky Mountain Cancer Centers, LLP
Colorado Springs
MSK Commack
Commack
Allina Health Cancer institute
Coon Rapids
Minnesota Oncology Hematology, PA
Coon Rapids
Texas Oncology - DFW
Dallas
Rocky Mountain Cancer Centers, LLP
Denver
Rocky Mountain Cancer Centers, LLP
Denver
Duke University Hospital
Durham
Duke University Medical Center
Durham
Duke University Medical Center, Duke Cancer Center
Durham
M Health Fairview Cancer Clinic-Edina
Edina
Minnesota Oncology Hematology, PA
Edina
UPMC Hillman Cancer Center Erie
Erie
Providence Regional Cancer Partnership
Everett
Providence Regional Medical Center Everett
Everett
Kaiser Permanente Fontana Medical Center
Fontana
Los Angeles Cancer Network - Fountain Vally
Fountain Valley
Minnesota Oncology Hematology, PA
Fridley
Los Angeles Cancer Network - Corporate Office
Glendale
Los Angeles Hematology Oncology Medical Group
Glendale
Los Angeles Hematology Oncology Medical Group
Glendale
Palo Verde Hematology Oncology
Glendale
UPMC Hillman Cancer Center at Arnold Palmer Pavilion, In Partnership with Excela Health
Greensburg
Northwest Cancer Specialists, P.C
Happy Valley
Kaiser Permanente South Bay Medical center
Harbor City
UPMC Hillman Cancer Center - Pinnacle (Community Osteopathic / Medical Sciences Pavillion)
Harrisburg
MSK Westchester
Harrison
The University of Texas MD Anderson Cancer Center
Houston
Kaiser Permanente Alton/Sand Canyon Medical Offices
Irvine
US Oncology Investigational Product Center (IPC)
Irving
US Oncology Investigational Products Center (IPC)
Irving
UPMC Hillman Cancer Center at Arnold Palmer Pavilion, In Partnership with Excela Health
Irwin
Rocky Mountain Cancer Centers, LLP
Lakewood
Rocky Mountain Cancer Centers, LLP
Littleton
Rocky Mountain Cancer Centers, LLP
Lone Tree
Rocky Mountain Cancer Centers, LLP
Longmont
Kaiser Permanente Los Angeles Medical Offices
Los Angeles
Kaiser Permanente West Los Angeles Medical Center
Los Angeles
Keck Hospital of USC
Los Angeles
Los Angeles General Medical Center
Los Angeles
Los Angeles Hematology Oncology Medical Group
Los Angeles
University of Southern California
Los Angeles
USC Norris Koreatown - Medical Oncology
Los Angeles
USC/Norris Comprehensive Cancer Center
Los Angeles
Norton Audubon Hospital
Louisville
Norton Brownsboro Hospital
Louisville
Norton Cancer Institute - Downtown
Louisville
Norton Cancer Institute, Audubon Hospital Campus
Louisville
Norton Cancer Institute, Brownsboro Hospital Campus
Louisville
Norton Cancer Institute, Downtown
Louisville
Norton Hospital
Louisville
Oncology & Hematology Associates of Southwest Virginia
Low Moor
Minnesota Oncology Hematology, PA
Maple Grove
M Health Fairview St. John's Hospital
Maplewood
Minnesota Oncology Hematology, PA
Maplewood
UPMC Hillman Cancer Center - Pinnacle (Ortenzio)
Mechanicsburg
Alliance for Multispecialty Research LLC.
Merriam
Mount Sinai Comprehensive Cancer Center
Miami Beach
Mount Sinai Medical Center
Miami Beach
MSK Monmouth
Middletown
Allina Health Cancer Institute (Virginia Piper Cancer Institute)
Minneapolis
Hennepin County Medical Center
Minneapolis
Minnesota Oncology Hematology, PA
Minneapolis
UPMC Hillman Cancer Center - Monroeville
Monroeville
MSK Bergen
Montvale
Henry-Joyce Cancer Clinic
Nashville
Memorial Solan Kettering Cancer Center- Main Campus
New York
Rockefeller Outpatient Pavilion (53rd Street)
New York
Providence Cancer Institute Newberg Clinic
Newberg
USC Norris Oncology/Hematology - Newport Beach
Newport Beach
Kaiser Permanente Ontario Medical Center
Ontario
Providence Cancer Institute Willamette Falls Clinic
Oregon City
Kaiser Permanente Panorama City Medical Center
Panorama City
Keck Medical Center of USC Pasadena
Pasadena
Los Angeles Hematology Oncology Medical Group
Pasadena
Mayo Clinic Building - Phoenix
Phoenix
Mayo Clinic Hospital
Phoenix
FirstHealth Cancer Center
Pinehurst
FirstHealth Moore Regional Hospital
Pinehurst
St. Clair Cancer Center Medical Oncology
Pittsburgh
UPMC Hillman Cancer Center
Pittsburgh
UPMC Hillman Cancer Center - Passavant (HOA)
Pittsburgh
UPMC Hillman Cancer Center - St Margarets
Pittsburgh
Northwest Cancer Specialists, P.C.
Portland
Providence Cancer Institute Franz Clinic
Portland
Providence Oncology and Hematology Care Clinic - Westside
Portland
Providence Portland Medical Center
Portland
Providence Portland Medical Center-Westside
Portland
Providence St. Vincent Medical Center
Portland
Providence St. Vincent Medical Center- Investigational Drug Services
Portland
Rocky Mountain Cancer Centers, LLP
Pueblo
Kaiser Permanente Riverside Medical Center
Riverside
Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care
Roanoke
North Memorial Health Cancer Center
Robbinsdale
Mayo Clinic Cancer Center Outpatient Pharmacy
Rochester
Metro Minnesota Community Oncology Research Consortium
Saint Louis Park
Park Nicollet Frauenshuh Cancer Center
Saint Louis Park
Regulatory Location: MMCORC
Saint Louis Park
Allina Health Cancer Institute-United(VPCI)
Saint Paul
Regions Hospital
Saint Paul
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care
Salem
Kaiser Permanente San Diego Mission Road (Regulatory and Lab Supplies)
San Diego
Kaiser Permanente Zion Medical Center
San Diego
Kaiser Permanente San Marcos Medical Offices
San Marcos
Mayo Clinic
Scottsdale
Avera Cancer Institute
Sioux Falls
Rocky Mountain Cancer Centers, LLP
Thornton
Northwest Cancer Specialists, P.C.
Tigard
MSK Nassau
Uniondale
Los Angeles Hematology Oncology Medical Group
Van Nuys
Northwest Cancer Specialists, P.C.
Vancouver
UPMC Hillman Cancer Center - Washington
Washington
Minnesota Oncology Hematology, PA Cornerstone Medical Specialty Center
Woodbury
Kaiser Permanente Woodland Hills Medical Center
Woodland Hills
Oncology & Hematology Associates of Southwest Virginia
Wytheville

Fuente Oficial

Ver en ClinicalTrials.gov