Single Arm Clinical Trial (Gut Microbiota and HCC)

Inclusion Criteria:

1. Age 18-75 years old, gender is not limited;

2. Confirmed imaging or histological diagnosis of unresectable HCC, BCLC stadium B or C;

3. Clinical diagnosis of HCC progression during TKIs combined with ICIs treatment;

4. Not suitable for local ablation or chemoembolization;

5. Child-Pugh Grade A;

6. ≥ 1 measurable lesion (RECIST v1.1)

7. ECOG PS 0-1

Exclusion Criteria:

1. Usage of antibiotics within 2 weeks prior enrollment;

2. Diagnosis of immunodeficiency (e.g. HIV, immunosuppressants)

3. Patients with known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation;

4. Female patients who are pregnant or breastfeeding;

5. Patients with untreated acute or chronic active hepatitis B or hepatitis C infection.

6. Patients are currently undergoing clinical trials of other drugs;

7. Patients are considered by the investigator to be unsuitable for inclusion.