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NCT06672523

Un estudio para evaluar el balance de masas, el metabolismo, la eliminación y los niveles del fármaco [14C]-BMS-986504 (MRTX1719) en participantes con tumores sólidos avanzados con deleción homocigótica del gen metiltioadenosina fosforilasa.

Reclutando Fase 1

Descripción

El objetivo de este estudio es evaluar el balance de masas, el metabolismo, la eliminación y los niveles del fármaco \[14C\]-BMS-986504 (MRTX1719) en participantes con tumores sólidos avanzados que presentan una deleción homocigótica del gen de la metiltioadenosina fosforilasa.

Criterios de Elegibilidad

Inclusion Criteria

  • Participants must have an advanced, unresectable, or metastatic solid tumor malignancy with a deletion of the methylthioadenosine phosphorylase (MTAP) gene.
  • Participants must have received, be refractory to, be ineligible for, or be intolerant of available standard care for their cancer.

Exclusion Criteria

  • Participants must not have a history of any surgical or medical conditions possibly affecting how the study drug is distributed, broken down (metabolized) and removed (excreted or eliminated) from the body.
  • Participants must not have participated in a clinical study involving a radiolabeled study drug within 12 months prior to admission to the research center.
  • Participants must not have a current or recent (within 3 months of study drug administration) gastrointestinal disease.
  • Other protocol-defined Inclusion/Exclusion criteria apply.

Información del Ensayo

NCT06672523
Reclutando
Fase 1
8 participantes
Mar 2025
Oct 2027

Ubicaciones3

Hungary (1)
ICON / PRA Magyarország Kft. Fázis I-es Klinikai Farmakológiai Vizsgálóhely
Budapest, 1076 Reclutando
Spain (2)
START Rioja, The START Center for cancer research
Logroño, 26006 Reclutando
Centro Integral Oncologico Clara Campal-Hospital HM Universitario Sanchinarro-START Madrid,
Madrid, 28050 Reclutando