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NCT06672523
Un estudio para evaluar el balance de masas, el metabolismo, la eliminación y los niveles del fármaco [14C]-BMS-986504 (MRTX1719) en participantes con tumores sólidos avanzados con deleción homocigótica del gen metiltioadenosina fosforilasa.
Reclutando
Fase 1
Descripción
El objetivo de este estudio es evaluar el balance de masas, el metabolismo, la eliminación y los niveles del fármaco \[14C\]-BMS-986504 (MRTX1719) en participantes con tumores sólidos avanzados que presentan una deleción homocigótica del gen de la metiltioadenosina fosforilasa.
Criterios de Elegibilidad
Inclusion Criteria
- Participants must have an advanced, unresectable, or metastatic solid tumor malignancy with a deletion of the methylthioadenosine phosphorylase (MTAP) gene.
- Participants must have received, be refractory to, be ineligible for, or be intolerant of available standard care for their cancer.
Exclusion Criteria
- Participants must not have a history of any surgical or medical conditions possibly affecting how the study drug is distributed, broken down (metabolized) and removed (excreted or eliminated) from the body.
- Participants must not have participated in a clinical study involving a radiolabeled study drug within 12 months prior to admission to the research center.
- Participants must not have a current or recent (within 3 months of study drug administration) gastrointestinal disease.
- Other protocol-defined Inclusion/Exclusion criteria apply.
Información del Ensayo
NCT06672523
Reclutando
Fase 1
8 participantes
Mar 2025
Oct 2027
Ubicaciones3
Hungary (1)
ICON / PRA Magyarország Kft. Fázis I-es Klinikai Farmakológiai Vizsgálóhely
Budapest, 1076 Reclutando
Spain (2)
START Rioja, The START Center for cancer research
Logroño, 26006 Reclutando
Centro Integral Oncologico Clara Campal-Hospital HM Universitario Sanchinarro-START Madrid,
Madrid, 28050 Reclutando