Back to All Combinations
WRN Deficient (MSI-H)
Good PrognosisGenes Involved
WRN
Treatment Implications
WRN helicase essential in MSI-H. Synthetic lethal approach.
Recommended Treatments
Immunotherapy
WRN inhibitor trials
Treatments to Avoid
No specific contraindications noted
Study References
Chan et al Nature
Key Statistics
3.00%
Prevalence in CRC
No
Targetable
Clinical Notes
Multiple WRN inhibitors in early trials.
Information
Category: Emerging Targets
Evidence Level: Level 3
Last Updated: Dec 7, 2025
Related Combinations
Medical Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult with your oncologist for personalized treatment decisions based on your specific situation.